PURPOSE: Diabetic retinopathy (DR) can lead to significant vision loss and blindness and has a particularly high prevalence in patients with type 1 diabetes (DM1). In this study, we investigate quantitative differences in optical coherence tomography angiography (OCTA) data between DM1 patients with no or mild signs of retinopathy and non-diabetic subjects. METHODS: Optical coherence tomography angiography (OCTA) imaging was performed on DM1 patients with no or mild nonproliferative diabetic retinopathy and healthy, age-matched controls. Parafoveal vessel density and foveal avascular zone (FAZ) area in the deep capillary plexus (DCP) and superficial capillary plexus (SCP) were calculated with automated quantification software and compared between patient cohorts. RESULTS: A significant decrease in parafoveal vessel density was seen in the DCP of DM1 patients compared to non-diabetic controls (57.0 ± 3.3% versus 60.7 ± 2.4%, p < 0.001). There was no significant difference in SCP parafoveal vessel density, DCP FAZ area, or SCP FAZ area between cohorts. CONCLUSION: M1 patients with no or mild signs of retinopathy have reduced parafoveal vessel density in the DCP on OCTA when compared to non-diabetic controls. These OCTA findings suggest that parafoveal capillary nonperfusion is an early process in DM1-related retinal changes and occurs initially at the level of the DCP. Further investigation is needed to understand the prognostic role of these vascular changes.
PURPOSE:Diabetic retinopathy (DR) can lead to significant vision loss and blindness and has a particularly high prevalence in patients with type 1 diabetes (DM1). In this study, we investigate quantitative differences in optical coherence tomography angiography (OCTA) data between DM1patients with no or mild signs of retinopathy and non-diabetic subjects. METHODS: Optical coherence tomography angiography (OCTA) imaging was performed on DM1patients with no or mild nonproliferative diabetic retinopathy and healthy, age-matched controls. Parafoveal vessel density and foveal avascular zone (FAZ) area in the deep capillary plexus (DCP) and superficial capillary plexus (SCP) were calculated with automated quantification software and compared between patient cohorts. RESULTS: A significant decrease in parafoveal vessel density was seen in the DCP of DM1patients compared to non-diabetic controls (57.0 ± 3.3% versus 60.7 ± 2.4%, p < 0.001). There was no significant difference in SCP parafoveal vessel density, DCP FAZ area, or SCP FAZ area between cohorts. CONCLUSION: M1 patients with no or mild signs of retinopathy have reduced parafoveal vessel density in the DCP on OCTA when compared to non-diabetic controls. These OCTA findings suggest that parafoveal capillary nonperfusion is an early process in DM1-related retinal changes and occurs initially at the level of the DCP. Further investigation is needed to understand the prognostic role of these vascular changes.
Authors: Mona Sharifi Sarabi; Maziyar M Khansari; Jiong Zhang; Sam Kushner-Lenhoff; Jin Kyu Gahm; Yuchuan Qiao; Amir H Kashani; Yonggang Shi Journal: IEEE J Biomed Health Inform Date: 2020-12-04 Impact factor: 5.772
Authors: Thomas S Hwang; Ahmed M Hagag; Jie Wang; Miao Zhang; Andrew Smith; David J Wilson; David Huang; Yali Jia Journal: JAMA Ophthalmol Date: 2018-08-01 Impact factor: 7.389
Authors: Richard B Rosen; Jorge S Andrade Romo; Brian D Krawitz; Shelley Mo; Amani A Fawzi; Rachel E Linderman; Joseph Carroll; Alexander Pinhas; Toco Y P Chui Journal: Am J Ophthalmol Date: 2019-01-26 Impact factor: 5.258
Authors: Jing Yan Yang; Qian Wang; Yan Ni Yan; Wen Jia Zhou; Ya Xing Wang; Shou Ling Wu; Ming Xia Yuan; Wen Bin Wei; Jost B Jonas Journal: Graefes Arch Clin Exp Ophthalmol Date: 2020-01-02 Impact factor: 3.117