Literature DB >> 2821028

Tissue inhibitor of metalloproteinases (TIMP) regulates extracellular type I collagen degradation by chondrocytes and endothelial cells.

J Gavrilovic1, R M Hembry, J J Reynolds, G Murphy.   

Abstract

A specific antiserum to purified rabbit tissue inhibitor of metalloproteinases (TIMP) was raised in sheep, characterized and used to investigate the role of TIMP in a model system. Chondrocytes and endothelial cells cultured on 14C-labelled type I collagen films and stimulated to produce collagenase were unable to degrade the films unless the anti-TIMP antibody was added. The degradation induced was inhibited by a specific anti-rabbit collagenase antibody. It was concluded that TIMP is a major regulatory factor in cell-mediated collagen degradation.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2821028     DOI： 10.1242/jcs.87.2.357

Source DB:  PubMed          Journal:  J Cell Sci        ISSN： 0021-9533            Impact factor:   5.285


  15 in total

Review 1.  The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer.

Authors:  G Cox; W P Steward; K J O'Byrne
Journal:  Thorax       Date:  1999-02       Impact factor: 9.139

2.  Cell-mediated degradation of type IV collagen and gelatin films is dependent on the activation of matrix metalloproteinases.

Authors:  S J Atkinson; R V Ward; J J Reynolds; G Murphy
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857

3.  * Understanding the Spatiotemporal Degradation Behavior of Aggrecanase-Sensitive Poly(ethylene glycol) Hydrogels for Use in Cartilage Tissue Engineering.

Authors:  Stanley Chu; Shankar Lalitha Sridhar; Umut Akalp; Stacey C Skaalure; Franck J Vernerey; Stephanie J Bryant
Journal:  Tissue Eng Part A       Date:  2017-05-24       Impact factor: 3.845

4.  Identification, purification and partial characterization of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in bovine pulmonary artery smooth muscle.

Authors:  Malay Mandal; Sudip Das; Tapati Chakraborti; Amritlal Mandal; Sajal Chakraborti
Journal:  Mol Cell Biochem       Date:  2003-12       Impact factor: 3.396

5.  Fibroblast growth factor stimulates the gene expression and production of tissue inhibitor of metalloproteinase-1 in bovine granulosa cells.

Authors:  H Hoshi; S Konno; M Kikuchi; Y Sendai; T Satoh
Journal:  In Vitro Cell Dev Biol Anim       Date:  1995 Jul-Aug       Impact factor: 2.416

6.  Regional and temporal changes in the synthesis of matrix metalloproteinases and TIMP-1 during development of the rabbit mandibular condyle.

Authors:  J J Breckon; R M Hembry; J J Reynolds; M C Meikle
Journal:  J Anat       Date:  1994-02       Impact factor: 2.610

7.  Studies of thrombin-induced proteoglycan release in the degradation of human and bovine cartilage.

Authors:  E Furmaniak-Kazmierczak; T D Cooke; R Manuel; A Scudamore; H Hoogendorn; A R Giles; M Nesheim
Journal:  J Clin Invest       Date:  1994-08       Impact factor: 14.808

8.  Up-regulation of TIMP-1 expression in B16-F10 melanoma cells suppresses their metastatic ability in chick embryo.

Authors:  R Khokha; M J Zimmer; S M Wilson; A F Chambers
Journal:  Clin Exp Metastasis       Date:  1992-11       Impact factor: 5.150

9.  The urokinase plasminogen activator (u-PA) and its inhibitor (PAI-1) in embryo-fetal bone formation in the human: an immunohistochemical study.

Authors:  C Häckel; K Radig; I Röse; A Roessner
Journal:  Anat Embryol (Berl)       Date:  1995-10

10.  The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1.

Authors:  R V Ward; R M Hembry; J J Reynolds; G Murphy
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.