Literature DB >> 28209594

Adolescents and Young Adults with Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia: Impact of Care at Specialized Cancer Centers on Survival Outcome.

Julie Wolfson1,2, Can-Lan Sun2, Laura Wyatt2, Wendy Stock3, Smita Bhatia4,2.   

Abstract

Background: Adolescents and young adults (AYA; 15-39 years) with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) experience inferior survival when compared with children. Impact of care at NCI-designated Comprehensive Cancer Centers (CCC) or Children's Oncology Group sites (COG) on survival disparities remains unstudied.
Methods: Using the Los Angeles cancer registry, we identified 1,870 ALL or AML patients between 1 and 39 years at diagnosis. Cox regression analyses assessed risk of mortality; younger age + CCC/COG served as the referent group. Logistic regression was used to determine odds of care at CCC/COG, adjusting for variables above.
Results: ALL outcome: AYAs at non-CCC/COG experienced inferior survival (15-21 years: HR = 1.9, P = 0.005; 22-29 years: HR = 2.6, P < 0.001; 30-39 years: HR = 3.0, P < 0.001). Outcome at CCC/COG was comparable between children and young AYAs (15-21 years: HR = 1.3, P = 0.3; 22-29 years: HR = 1.2, P = 0.2) but was inferior for 30- to 39-year-olds (HR = 3.4, P < 0.001). AML outcome: AYAs at non-CCC/COG experienced inferior outcome (15-21 years: HR = 1.8, P = 0.02; 22-39 years: HR = 1.4, P = 0.06). Outcome at CCC/COG was comparable between children and 15- to 21-year-olds (HR = 1.3, P = 0.4) but was inferior for 22- to 39-year-olds (HR = 1.7, P = 0.05). Access: 15- to 21-year-olds were less likely to use CCC/COG than children (P < 0.001). In 22- to 39-year-olds, public/uninsured (ALL: P = 0.004; AML<0.001), African American/Hispanics (ALL: P = 0.03), and 30- to 39-year-olds (ALL: P = 0.03) were less likely to use CCC/COG.Conclusions: Poor survival in AYAs with ALL and AML is mitigated by care at CCC/COG. Barriers to CCC/COG care include public/uninsured, and African American/Hispanic race/ethnicity.Impact: Care at CCC/COG explains, in part, inferior outcomes in AYAs with ALL and AML. Key sociodemographic factors serve as barriers to care at specialized centers. Cancer Epidemiol Biomarkers Prev; 26(3); 312-20. ©2017 AACR. ©2017 American Association for Cancer Research.

Entities:  

Mesh：

Year:  2017        PMID： 28209594      PMCID： PMC5546404          DOI： 10.1158/1055-9965.EPI-16-0722

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  28 in total

Review 1.  Understanding racial disparities in cancer treatment and outcomes.

Authors:  Arden M Morris; Kim F Rhoads; Steven C Stain; John D Birkmeyer
Journal:  J Am Coll Surg       Date:  2010-07       Impact factor: 6.113

2.  Failure to comply with NCCN guidelines for the management of pancreatic cancer compromises outcomes.

Authors:  Brendan C Visser; Yifei Ma; Yulia Zak; George A Poultsides; Jeffrey A Norton; Kim F Rhoads
Journal:  HPB (Oxford)       Date:  2012-06-12       Impact factor: 3.647

3.  A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults.

Authors:  Virginia Perez-Andreu; Kathryn G Roberts; Heng Xu; Colton Smith; Hui Zhang; Wenjian Yang; Richard C Harvey; Debbie Payne-Turner; Meenakshi Devidas; I-Ming Cheng; William L Carroll; Nyla A Heerema; Andrew J Carroll; Elizabeth A Raetz; Julie M Gastier-Foster; Guido Marcucci; Clara D Bloomfield; Krzysztof Mrózek; Jessica Kohlschmidt; Wendy Stock; Steven M Kornblau; Marina Konopleva; Elisabeth Paietta; Jacob M Rowe; Selina M Luger; Martin S Tallman; Michael Dean; Esteban G Burchard; Dara G Torgerson; Feng Yue; Yanli Wang; Ching-Hon Pui; Sima Jeha; Mary V Relling; William E Evans; Daniela S Gerhard; Mignon L Loh; Cheryl L Willman; Stephen P Hunger; Charles G Mullighan; Jun J Yang
Journal:  Blood       Date:  2014-12-02       Impact factor: 22.113

4.  Hospital volume and operative mortality in cancer surgery: a national study.

Authors:  Emily V A Finlayson; Philip P Goodney; John D Birkmeyer
Journal:  Arch Surg       Date:  2003-07

5.  Impact of care at comprehensive cancer centers on outcome: Results from a population-based study.

Authors:  Julie A Wolfson; Can-Lan Sun; Laura P Wyatt; Arti Hurria; Smita Bhatia
Journal:  Cancer       Date:  2015-07-28       Impact factor: 6.860

6.  Access to pediatric cancer care by age, race, and diagnosis, and outcomes of cancer treatment in pediatric and adolescent patients in the state of Georgia.

Authors:  Della L Howell; Kevin C Ward; Harland D Austin; John L Young; William G Woods
Journal:  J Clin Oncol       Date:  2007-10-10       Impact factor: 44.544

7.  Impact of treatment site in adolescents and young adults with central nervous system tumors.

Authors:  Julie Wolfson; Can-Lan Sun; Tongjun Kang; Laura Wyatt; Massimo D'Appuzzo; Smita Bhatia
Journal:  J Natl Cancer Inst       Date:  2014-09-01       Impact factor: 13.506

8.  Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children's Oncology Group.

Authors:  Jason Canner; Todd A Alonzo; Janet Franklin; David R Freyer; Alan Gamis; Robert B Gerbing; Beverly J Lange; Soheil Meshinchi; William G Woods; John Perentesis; John Horan
Journal:  Cancer       Date:  2013-09-19       Impact factor: 6.860

9.  Delivering High-Quality Cancer Care: The Critical Role of Quality Measurement.

Authors:  Tracy Spinks; Patricia A Ganz; George W Sledge; Laura Levit; James A Hayman; Timothy J Eberlein; Thomas W Feeley
Journal:  Healthc (Amst)       Date:  2014-03-01

10.  Do hospitals that serve a high percentage of Medicaid patients perform well on evidence-based guidelines for colon cancer care?

Authors:  Kim F Rhoads; Justine V Ngo; Yifei Ma; Lyen Huang; Mark L Welton; R Adams Dudley
Journal:  J Health Care Poor Underserved       Date:  2013-08
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  24 in total

1.  Treatment Complications and Survival Among Children and Young Adults With Acute Lymphoblastic Leukemia.

Authors:  Elysia M Alvarez; Marcio Malogolowkin; Jeffrey S Hoch; Qian Li; Ann Brunson; Brad H Pollock; Lori Muffly; Ted Wun; Theresa H M Keegan
Journal:  JCO Oncol Pract       Date:  2020-06-11

2.  Survival impact of postoperative radiotherapy timing in pediatric and adolescent medulloblastoma.

Authors:  Alexander L Chin; Everett J Moding; Sarah S Donaldson; Iris C Gibbs; Scott G Soltys; Susan M Hiniker; Erqi L Pollom
Journal:  Neuro Oncol       Date:  2018-07-05       Impact factor: 12.300

3.  Clinical features and outcomes of patients with Shwachman-Diamond syndrome and myelodysplastic syndrome or acute myeloid leukaemia: a multicentre, retrospective, cohort study.

Authors:  Kasiani C Myers; Elissa Furutani; Edie Weller; Bradford Siegele; Ashley Galvin; Valerie Arsenault; Blanche P Alter; Farid Boulad; Carlos Bueso-Ramos; Lauri Burroughs; Paul Castillo; James Connelly; Stella M Davies; Courtney D DiNardo; Iftikhar Hanif; Richard H Ho; Nicole Karras; Michelle Manalang; Lisa J McReynolds; Taizo A Nakano; Grzegorz Nalepa; Maxim Norkin; Matthew J Oberley; Etan Orgel; Yves D Pastore; Joseph Rosenthal; Kelly Walkovich; Jordan Larson; Maggie Malsch; M Tarek Elghetany; Mark D Fleming; Akiko Shimamura
Journal:  Lancet Haematol       Date:  2019-12-23       Impact factor: 18.959

4.  Survival by Race and Ethnicity in Pediatric and Adolescent Patients With Hodgkin Lymphoma: A Children's Oncology Group Study.

Authors:  Justine M Kahn; Kara M Kelly; Qinglin Pei; Rizvan Bush; Debra L Friedman; Frank G Keller; Smita Bhatia; Tara O Henderson; Cindy L Schwartz; Sharon M Castellino
Journal:  J Clin Oncol       Date:  2019-09-20       Impact factor: 44.544

5.  Causes of Inferior Outcome in Adolescents and Young Adults with Acute Lymphoblastic Leukemia: Across Oncology Services and Regardless of Clinical Trial Enrollment.

Authors:  Julie A Wolfson; Joshua S Richman; Can-Lan Sun; Wendy Landier; Karen Leung; Eileen P Smith; Margaret O'Donnell; Smita Bhatia
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2018-09-27       Impact factor: 4.254

6.  Attendance at National Cancer Institute and Children's Oncology Group Facilities for Children, Adolescents, and Young Adults with Cancer in Pennsylvania: A Population-Based Study.

Authors:  Pooja Rao; Joel E Segel; Lisa M McGregor; Eugene J Lengerich; Joseph J Drabick; Barbara Miller
Journal:  J Adolesc Young Adult Oncol       Date:  2019-10-10       Impact factor: 2.223

7.  Pediatric-inspired protocols in adult acute lymphoblastic leukemia: are the results bearing fruit?

Authors:  Lori Muffly; Emily Curran
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2019-12-06

8.  Resource Utilization and Costs in Adolescents Treated for Cancer in Pediatric vs Adult Institutions.

Authors:  Paul C Nathan; Karen E Bremner; Ning Liu; Sumit Gupta; Mark L Greenberg; Mary L McBride; Murray D Krahn; Claire de Oliveira
Journal:  J Natl Cancer Inst       Date:  2019-03-01       Impact factor: 13.506

Review 9.  Disparities in Survival and Health Outcomes in Childhood Leukemia.

Authors:  Lena E Winestone; Richard Aplenc
Journal:  Curr Hematol Malig Rep       Date:  2019-06       Impact factor: 3.952

10.  Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study.

Authors:  Eugene Suh; Kayla L Stratton; Wendy M Leisenring; Paul C Nathan; Jennifer S Ford; David R Freyer; Jennifer L McNeer; Wendy Stock; Marilyn Stovall; Kevin R Krull; Charles A Sklar; Joseph P Neglia; Gregory T Armstrong; Kevin C Oeffinger; Leslie L Robison; Tara O Henderson
Journal:  Lancet Oncol       Date:  2020-02-14       Impact factor: 41.316
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