Ajay Malhotra1, Mia Zhang2, Xiao Wu3, Shanu Jindal4, David Durand5, Naila Makhani6. 1. Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar St, New Haven, CT 06520-8042, United States. Electronic address: ajay.malhotra@yale.edu. 2. Griffith University, Brisbane, Australia. Electronic address: mia.zhang.m@gmail.com. 3. Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, United States. Electronic address: xiao.wu@yale.edu. 4. University of North Carolina, School of Public Health, Chapel Hill, NC, United States. Electronic address: s_jindal3@yahoo.com. 5. Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, United States. Electronic address: david.durand@yale.edu. 6. Department of Pediatrics (Neurology) and of Neurology, Yale School of Medicine, New Haven, CT, United States. Electronic address: naila.makhani@yale.edu.
Abstract
BACKGROUND: Miller Fisher syndrome (MFS) is a rare demyelinating condition which may have involvement of cranial nerves. There are a few case reports of optic pathway involvement in children. We describe 3 patients with optic pathway enhancement in pediatric patients with MFS. CASE SERIES: We retrospectively reviewed brain imaging findings in 17 pediatric patients with of Guillain-Barré syndrome (GBS) meeting Brighton criteria who had brain MRIs performed during their acute illness. Cranial nerve enhancement was seen in 6/17 patients and optic nerve/chiasm enhancement was seen in 3 patients. CONCLUSION: Cranial nerve enhancement and optic pathway in particular, can be seen in patients with MFS. Imaging findings do not always correlate with clinical manifestations of cranial nerve involvement.
BACKGROUND:Miller Fisher syndrome (MFS) is a rare demyelinating condition which may have involvement of cranial nerves. There are a few case reports of optic pathway involvement in children. We describe 3 patients with optic pathway enhancement in pediatric patients with MFS. CASE SERIES: We retrospectively reviewed brain imaging findings in 17 pediatric patients with of Guillain-Barré syndrome (GBS) meeting Brighton criteria who had brain MRIs performed during their acute illness. Cranial nerve enhancement was seen in 6/17 patients and optic nerve/chiasm enhancement was seen in 3 patients. CONCLUSION: Cranial nerve enhancement and optic pathway in particular, can be seen in patients with MFS. Imaging findings do not always correlate with clinical manifestations of cranial nerve involvement.