| Literature DB >> 28209055 |
Jian He1, Qian Shao1, Qingfeng Wu1, Jin-Quan Yu1.
Abstract
Pd(II)-catalyzed enantioselective borylation of C(sp3)-H bonds has been realized for the first time using chiral acetyl-protected aminomethyl oxazoline ligands. This reaction is compatible with carbocyclic amides containing α-tertiary as well as α-quaternary carbon centers. The chiral β-borylated amides are useful synthons for the synthesis of chiral β-hydroxylated, β-fluorinated, and β-arylated carboxylic acids.Entities:
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Year: 2017 PMID： 28209055 DOI： 10.1021/jacs.6b13389
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419