Literature DB >> 2820635

Pyrimidinone (bropirimine) mediated alteration of T lymphocyte subsets during murine cytomegalovirus infection.

R J Brideau1, J A Nicholas.   

Abstract

Murine cytomegalovirus (MCMV) infection of mice resulted in suppression of mitogen induced proliferation and interleukin 2 (IL-2) responses of splenic cells. This suppression was also evident as a reduction in the number of cells expressing Thy-1 or L3T4 and a reduction in the ratio of T helper/T suppressor cells. The pyrimidinone compound, bropirimine, when administered to MCMV infected mice was able to restore mitogen-induced proliferative and IL-2 responses of splenic cells, to increase the number of cells expressing Thy-1 or L3T4, to restore the ratio of T helper/T suppressor cells and to increase the number of cells inducible for expression of IL-2 receptors.

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Year:  1987        PMID： 2820635      PMCID： PMC1542767     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  22 in total

1.  Correlation of the suppression of mitogen responsiveness and the mixed lymphocyte reaction with the proliferative response to viral antigen of splenic lymphocytes from cytomegalovirus-infected mice.

Authors:  D K Kelsey; J C Overall; L A Glasgow
Journal:  J Immunol       Date:  1978-08       Impact factor: 5.422

2.  Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis.

Authors:  W P Carney; R H Rubin; R A Hoffman; W P Hansen; K Healey; M S Hirsch
Journal:  J Immunol       Date:  1981-06       Impact factor: 5.422

3.  Murine cytomegalovirus infection in the spleen and its relationship to immunosuppression.

Authors:  L Loh; J B Hudson
Journal:  Infect Immun       Date:  1981-06       Impact factor: 3.441

4.  Mechanisms of immunosuppression in cytomegaloviral mononucleosis.

Authors:  C R Rinaldo; W P Carney; B S Richter; P H Black; M S Hirsch
Journal:  J Infect Dis       Date:  1980-04       Impact factor: 5.226

5.  Effect of cytosine arabinoside and 5-iodo-2'-deoxyuridine on a cytomegalovirus infection in newborn mice.

Authors:  D K Kelsey; E R Kern; J C Overall; L A Glasgow
Journal:  Antimicrob Agents Chemother       Date:  1976-03       Impact factor: 5.191

6.  Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

Authors:  T R Malek; R J Robb; E M Shevach
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

7.  5-halo-6-phenyl pyrimidinones: new molecules with cancer therapeutic potential and interferon-inducing capacity are strong inducers of murine natural killer cells.

Authors:  E Lotzová; C A Savary; D A Stringfellow
Journal:  J Immunol       Date:  1983-02       Impact factor: 5.422

8.  Immunosuppressive effect of murine cytomegalovirus.

Authors:  L Loh; J B Hudson
Journal:  Infect Immun       Date:  1980-01       Impact factor: 3.441

9.  Two distinct factors are required for induction of T-cell growth.

Authors:  E L Larsson; N N Iscove; A Coutinho
Journal:  Nature       Date:  1980-02-14       Impact factor: 49.962

10.  The functional relationship of the interleukins.

Authors:  K A Smith; L B Lachman; J J Oppenheim; M F Favata
Journal:  J Exp Med       Date:  1980-06-01       Impact factor: 14.307
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  2 in total

1.  Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, interferon, and bropirimine.

Authors:  D F Smee; J L Morris; J A Leonhardt; J R Mead; A Holy; R W Sidwell
Journal:  Antimicrob Agents Chemother       Date:  1992-09       Impact factor: 5.191

2.  Induction of apoptosis of T cells by infecting mice with murine cytomegalovirus.

Authors:  H Yoshida; H Sumichika; S Hamano; X He; Y Minamishima; G Kimura; K Nomoto
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103
  2 in total

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