Literature DB >> 28203048

Atypical femoral shaft fractures secondary to long-term bisphosphonate therapy.

Cemil Kayali1, Taskin Altay1, Firat Ozan2, Serkan Sozkesen3, Kamil Yamak1.   

Abstract

BACKGROUND: Bisphosphonates (BPs) are one of the most commonly used agents in the treatment of post-menopausal osteoporosis and other metabolic bone diseases.
METHODS: Between 2010 and 2015, data of 22 osteoporotic women with femoral fractures due to low-energy trauma who received BPs previously were analysed.
RESULTS: The mean duration of BP therapy was 7.6 years. The mean duration of union was 7.4 months. Five patients had non-union. Stress reaction was observed in the contralateral femur in 11 patients.
CONCLUSION: Radiographic studies should be performed on a regular basis to prevent atypical femoral fractures in patients on long-term BP therapy.

Entities:  

Keywords:  Adverse effects; Atypical femoral fracture; Bisphosohonate; Femoral shaft fracture; Stress reaction

Year:  2017        PMID: 28203048      PMCID: PMC5293726          DOI: 10.1016/j.jor.2017.01.002

Source DB:  PubMed          Journal:  J Orthop        ISSN: 0972-978X


  29 in total

1.  Subtrochanteric femoral fractures in patients receiving long-term alendronate therapy: imaging features.

Authors:  Sarah Shock Chan; Zehava Sadka Rosenberg; Keith Chan; Craig Capeci
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2.  Long-term safety of bisphosphonates.

Authors:  Susan M Ott
Journal:  J Clin Endocrinol Metab       Date:  2005-03       Impact factor: 5.958

Review 3.  Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates.

Authors:  Jeri W Nieves; Felicia Cosman
Journal:  Curr Osteoporos Rep       Date:  2010-03       Impact factor: 5.096

Review 4.  Long-term bisphosphonate usage and subtrochanteric insufficiency fractures: a cause for concern?

Authors:  R S Yoon; J S Hwang; K S Beebe
Journal:  J Bone Joint Surg Br       Date:  2011-10

5.  Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs.

Authors:  M R Allen; D B Burr
Journal:  Osteoporos Int       Date:  2007-08-21       Impact factor: 4.507

Review 6.  Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research.

Authors:  Elizabeth Shane; David Burr; Bo Abrahamsen; Robert A Adler; Thomas D Brown; Angela M Cheung; Felicia Cosman; Jeffrey R Curtis; Richard Dell; David W Dempster; Peter R Ebeling; Thomas A Einhorn; Harry K Genant; Piet Geusens; Klaus Klaushofer; Joseph M Lane; Fergus McKiernan; Ross McKinney; Alvin Ng; Jeri Nieves; Regis O'Keefe; Socrates Papapoulos; Tet Sen Howe; Marjolein C H van der Meulen; Robert S Weinstein; Michael P Whyte
Journal:  J Bone Miner Res       Date:  2013-10-01       Impact factor: 6.741

7.  Subtrochanteric and diaphyseal femur fractures in patients treated with alendronate: a register-based national cohort study.

Authors:  Bo Abrahamsen; Pia Eiken; Richard Eastell
Journal:  J Bone Miner Res       Date:  2009-06       Impact factor: 6.741

8.  Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study.

Authors:  B A Lenart; A S Neviaser; S Lyman; C C Chang; F Edobor-Osula; B Steele; M C H van der Meulen; D G Lorich; J M Lane
Journal:  Osteoporos Int       Date:  2008-12-09       Impact factor: 4.507

9.  Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series.

Authors:  Reina Armamento-Villareal; Nicola Napoli; Kathryn Diemer; Marcus Watkins; Roberto Civitelli; Steven Teitelbaum; Deborah Novack
Journal:  Calcif Tissue Int       Date:  2009-06-23       Impact factor: 4.333

10.  Bilateral fractures of the femur diaphysis in a patient with rheumatoid arthritis on long-term treatment with alendronate: clues to the mechanism of increased bone fragility.

Authors:  Matthijs P Somford; Frits W Draijer; Bregje J W Thomassen; Pascale M Chavassieux; Georges Boivin; Socrates E Papapoulos
Journal:  J Bone Miner Res       Date:  2009-10       Impact factor: 6.741

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  2 in total

Review 1.  Atypical femur fractures: a distinctive tract of adult hypophosphatasia.

Authors:  Francesca Marini; Maria Luisa Brandi
Journal:  Clin Cases Miner Bone Metab       Date:  2017-12-27

Review 2.  Surgical Treatment for Bisphosphonate-related Atypical Femoral Fracture: A Systematic Review.

Authors:  Adel Ebrahimpour; Mehrdad Sadighi; Amir Human Hoveidaei; Mohammadreza Chehrassan; Reza Minaei; Hamed Vahedi; Sm Javad Mortazavi
Journal:  Arch Bone Jt Surg       Date:  2021-05
  2 in total

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