Literature DB >> 2820271

Midazolam antagonizes the analgesic effect of morphine in rats.

A M Daghero, E L Bradley, I Kissin.   

Abstract

The effect of midazolam on morphine analgesia was studied in 54 rats. Analgesia was determined by measuring threshold for motor response to noxious pressure applied to the tail. Midazolam (0.5 mg/kg) decreased the morphine-induced (1 mg/kg) increase in the reaction threshold by one-half. Flumazepil (Ro 15-1788), a specific antagonist of benzodiazepines, prevented inhibition of morphine antinociception by midazolam. These findings demonstrate that midazolam partially antagonizes the analgesic effect of morphine and, in addition, that the antagonism of midazolam on morphine analgesia is mediated by benzodiazepine receptors.

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Year:  1987        PMID： 2820271

Source DB:  PubMed          Journal:  Anesth Analg        ISSN： 0003-2999            Impact factor:   5.108


  6 in total

1.  Withdrawal following sufentanil/propofol and sufentanil/midazolam. Sedation in surgical ICU patients: correlation with central nervous parameters and endogenous opioids.

Authors:  Maria Korak-Leiter; Rudolf Likar; Michael Oher; Ernst Trampitsch; Gerda Ziervogel; Joseph V Levy; Enno C Freye
Journal:  Intensive Care Med       Date:  2005-02-16       Impact factor: 17.440

2.  Pain-induced analgesia mediated by mesolimbic reward circuits.

Authors:  R W Gear; K O Aley; J D Levine
Journal:  J Neurosci       Date:  1999-08-15       Impact factor: 6.167

3.  Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.

Authors:  S M Cartmell; D Mitchell
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

4.  Diazepam enhances fentanyl and diminishes meperidine antinociception.

Authors:  S A Bergman; R L Wyn; G Williams
Journal:  Anesth Prog       Date:  1988 Sep-Oct

5.  [Pain and consciousness. Articles from the summer workshop held by the German Interdisciplinary Collaboration for Pain Therapy (DIVS) in 2005].

Authors:  H Laubenthal; M Valet; T Sprenger; A Wöller; T R Tölle; H Röpcke; S Wirz; C Schröter; M Schiltenwolf; P Henningsen; T Sundermeier; H J Ebell; N Kohnen; W Häuser
Journal:  Schmerz       Date:  2007-06       Impact factor: 1.107

Review 6.  Benzodiazepines for restless legs syndrome.

Authors:  Karla Carlos; Gilmar F Prado; Camila Dm Teixeira; Cristiane Conti; Marcio M de Oliveira; Lucila Bf Prado; Luciane Bc Carvalho
Journal:  Cochrane Database Syst Rev       Date:  2017-03-20
  6 in total

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