Literature DB >> 28202490

Merck ends trial of potential Alzheimer's drug verubecestat.

Nigel Hawkes1.   

Abstract

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Year:  2017        PMID： 28202490     DOI： 10.1136/bmj.j845

Source DB:  PubMed          Journal:  BMJ        ISSN： 0959-8138


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  20 in total

Review 1.  Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology.

Authors:  Jianping Guo; Ji Cheng; Brian J North; Wenyi Wei
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2017-07-08       Impact factor: 10.680

Review 2.  Tau tubulin kinases in proteinopathy.

Authors:  Laura M Taylor; Pamela J McMillan; Brian C Kraemer; Nicole F Liachko
Journal:  FEBS J       Date:  2019-05-22       Impact factor: 5.542

Review 3.  Regulation of microRNAs in Alzheimer´s disease, type 2 diabetes, and aerobic exercise training.

Authors:  Ricardo Augusto Leoni De Sousa; Alex Cleber Improta-Caria
Journal:  Metab Brain Dis       Date:  2022-01-25       Impact factor: 3.584

Review 4.  Recent Progress in the Pharmacotherapy of Alzheimer's Disease.

Authors:  Rita Khoury; Kush Patel; Jake Gold; Stephanie Hinds; George T Grossberg
Journal:  Drugs Aging       Date:  2017-11       Impact factor: 3.923

5.  MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.

Authors:  Bing-Lin Zhu; Yan Long; Wei Luo; Zhen Yan; Yu-Jie Lai; Li-Ge Zhao; Wei-Hui Zhou; Yan-Jiang Wang; Lin-Lin Shen; Lu Liu; Xiao-Juan Deng; Xue-Feng Wang; Fei Sun; Guo-Jun Chen
Journal:  Brain       Date:  2019-01-01       Impact factor: 13.501

6.  Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation.

Authors:  Christian R O Bartling; Thomas M T Jensen; Shawna M Henry; Anna L Colliander; Vita Sereikaite; Marcella Wenzler; Palash Jain; Hans M Maric; Kasper Harpsøe; Søren W Pedersen; Louise S Clemmensen; Linda M Haugaard-Kedström; David E Gloriam; Angela Ho; Kristian Strømgaard
Journal:  J Am Chem Soc       Date:  2021-01-05       Impact factor: 15.419

7.  Restoring synaptic plasticity and memory in mouse models of Alzheimer's disease by PKR inhibition.

Authors:  Kyoung-Doo Hwang; Myeong Seong Bak; Sang Jeong Kim; Sangmyung Rhee; Yong-Seok Lee
Journal:  Mol Brain       Date:  2017-12-13       Impact factor: 4.041

Review 8.  Alzheimer's disease drug development pipeline: 2017.

Authors:  Jeffrey Cummings; Garam Lee; Travis Mortsdorf; Aaron Ritter; Kate Zhong
Journal:  Alzheimers Dement (N Y)       Date:  2017-05-24

9.  Whole transcriptome profiling of Late-Onset Alzheimer's Disease patients provides insights into the molecular changes involved in the disease.

Authors:  Anita Annese; Caterina Manzari; Claudia Lionetti; Ernesto Picardi; David S Horner; Matteo Chiara; Mariano Francesco Caratozzolo; Apollonia Tullo; Bruno Fosso; Graziano Pesole; Anna Maria D'Erchia
Journal:  Sci Rep       Date:  2018-03-09       Impact factor: 4.379

10.  Synergistic toxicity between tau and amyloid drives neuronal dysfunction and neurodegeneration in transgenic C. elegans.

Authors:  Sarah J Benbow; Timothy J Strovas; Martin Darvas; Aleen Saxton; Brian C Kraemer
Journal:  Hum Mol Genet       Date:  2020-02-01       Impact factor: 6.150
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