Literature DB >> 2819864

Characterization of the phosphatidylinositol-glycan membrane anchor of human placental alkaline phosphatase.

A D Howard, J Berger, L Gerber, P Familletti, S Udenfriend.   

Abstract

Placental alkaline phosphatase [orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] is a member of a diverse group of membrane proteins whose attachment to the lipid bilayer is mediated by a phosphatidylinositol-glycan. To investigate structural aspects of the glycolipid anchor, cultured WISH cells were used because we found that they produce the enzyme in abundant quantities. When cell suspensions were incubated with purified phosphatidylinositol-specific phospholipase C, most of the placental alkaline phosphatase was released from membranes in a hydrophilic form. On incubation of the cells with [14C]ethanolamine, [14C]myristic acid, or myo-[3H]inositol, each was incorporated into the phosphatase near the carboxyl terminus, showing that these components, which are found in other phosphatidylinositol membrane-linked proteins, are also present in placental alkaline phosphatase.

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Year:  1987        PMID： 2819864      PMCID： PMC299006          DOI： 10.1073/pnas.84.17.6055

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Enzymatic properties of phosphatidylinositol inositolphosphohydrolase from Bacillus cereus. Substrate dilution in detergent-phospholipid micelles and bilayer vesicles.

Authors:  R Sundler; A W Alberts; P R Vagelos
Journal:  J Biol Chem       Date:  1978-06-25       Impact factor: 5.157

2.  Comparison of human alkaline phosphatase isoenzymes. Structural evidence for three protein classes.

Authors:  M J McKenna; T A Hamilton; H H Sussman
Journal:  Biochem J       Date:  1979-07-01       Impact factor: 3.857

3.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

4.  Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C.

Authors:  M G Low; J B Finean
Journal:  Biochem J       Date:  1977-10-01       Impact factor: 3.857

5.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

6.  Amino acid analysis of proteins and peptides at the picomole level: the fluorescamine amino acid analyzer.

Authors:  S Stein; L Brink
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

7.  Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus. I. purification, properties and phosphatase-releasing activity.

Authors:  H Ikezawa; M Yamanegi; R Taguchi; T Miyashita; T Ohyabu
Journal:  Biochim Biophys Acta       Date:  1976-11-19

8.  Specificity of fatty acid acylation of cellular proteins.

Authors:  E N Olson; D A Towler; L Glaser
Journal:  J Biol Chem       Date:  1985-03-25       Impact factor: 5.157

9.  Myristylation of the membrane form of a Trypanosoma brucei variant surface glycoprotein.

Authors:  M A Ferguson; G A Cross
Journal:  J Biol Chem       Date:  1984-03-10       Impact factor: 5.157

10.  Evidence that three structural genes code for human alkaline phosphatases.

Authors:  L E Seargeant; R A Stinson
Journal:  Nature       Date:  1979-09-13       Impact factor: 49.962
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  18 in total

1.  Bile duct ligation-induced redistribution of canalicular antigen in rat hepatocyte plasma membranes demonstrated by immunogold quantitation.

Authors:  L Landmann; P J Meier; L Bianchi
Journal:  Histochemistry       Date:  1990

2.  Erv26p directs pro-alkaline phosphatase into endoplasmic reticulum-derived coat protein complex II transport vesicles.

Authors:  Catherine A Bue; Christine M Bentivoglio; Charles Barlowe
Journal:  Mol Biol Cell       Date:  2006-09-06       Impact factor: 4.138

3.  Processing at the carboxyl terminus of nascent placental alkaline phosphatase in a cell-free system: evidence for specific cleavage of a signal peptide.

Authors:  C A Bailey; L Gerber; A D Howard; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

4.  Transport in isolated rat hepatocytes of the phospho-oligosaccharide that mimics insulin action. Effects of adrenalectomy and glucocorticoid treatment.

Authors:  J F Alvarez; J A Sánchez-Arias; A Guadaño; F Estévez; I Varela; J E Felíu; J M Mato
Journal:  Biochem J       Date:  1991-03-01       Impact factor: 3.857

5.  Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.

Authors:  R Micanovic; L D Gerber; J Berger; K Kodukula; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

6.  Biosynthesis of glycosylphosphatidylinositol-anchored human placental alkaline phosphatase: evidence for a phospholipase C-sensitive precursor and its post-attachment conversion into a phospholipase C-resistant form.

Authors:  Y W Wong; M G Low
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

7.  Structure of the glycosylphosphatidylinositol membrane anchor of human placental alkaline phosphatase.

Authors:  C A Redman; J E Thomas-Oates; S Ogata; Y Ikehara; M A Ferguson
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857

8.  Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme.

Authors:  R Micanovic; C A Bailey; L Brink; L Gerber; Y C Pan; J D Hulmes; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

9.  Bip/GRP78 but not calnexin associates with a precursor of glycosylphosphatidylinositol-anchored protein.

Authors:  K Oda; I Wada; N Takami; T Fujiwara; Y Misumi; Y Ikehara
Journal:  Biochem J       Date:  1996-06-01       Impact factor: 3.857

10.  Conversion of secretory proteins into membrane proteins by fusing with a glycosylphosphatidylinositol anchor signal of alkaline phosphatase.

Authors:  K Oda; J Cheng; T Saku; N Takami; M Sohda; Y Misumi; Y Ikehara; J L Millán
Journal:  Biochem J       Date:  1994-07-15       Impact factor: 3.857
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