Literature DB >> 28198104

Dakin's solution: is there a place for it in the 21st century?

Bruno Duarte1, Joana Cabete1, Ana Formiga2, José Neves2.   

Abstract

Dakin's solution (DS) is a time-honoured antiseptic that still remains part of the wound care armamentarium. In spite of its cytotoxicity, some question its use in the current era. We report the case of a 52-year-old diabetic woman who was admitted for sepsis because of a severely infected diabetic foot. Urgent surgical drainage and debridement left a 9 × 9-cm deep, complex, infected wound with both bone and tendon involvement. Treatment with local negative pressure was unsuccessful. DS was regularly instilled through a tube left in the wound dressing. A marked improvement was observed with this strategy as the wound bed was much cleaner and fully granulated after 6 weeks. No adverse effects were noted. This case debunks the myth that topical antiseptics necessarily impair wound healing. DS can still be considered an option for difficult-to-treat, complex and heavily infected wounds.
© 2017 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Entities:  

Keywords:  Dakin's solution; Diabetic foot; Wound healing

Mesh:

Substances:

Year:  2017        PMID: 28198104      PMCID: PMC7949605          DOI: 10.1111/iwj.12728

Source DB:  PubMed          Journal:  Int Wound J        ISSN: 1742-4801            Impact factor:   3.315


  10 in total

1.  Bacterial load predicts healing rate in neuropathic diabetic foot ulcers.

Authors:  Ling Xu; Susan V McLennan; Lisa Lo; Anas Natfaji; Thyra Bolton; Yu Liu; Stephen M Twigg; Dennis K Yue
Journal:  Diabetes Care       Date:  2007-02       Impact factor: 19.112

2.  Dakin's solution: past, present, and future.

Authors:  Jeffrey M Levine
Journal:  Adv Skin Wound Care       Date:  2013-09       Impact factor: 2.347

3.  The use of Dakin's solution in chronic wounds: a clinical perspective case series.

Authors:  Patricia Cornwell; Mary Arnold-Long; Stephanie Bernahl Barss; Myra F Varnado
Journal:  J Wound Ostomy Continence Nurs       Date:  2010 Jan-Feb       Impact factor: 1.741

4.  Dakin's solution: historical perspective and current practice.

Authors:  Meghan McCullough; Grant W Carlson
Journal:  Ann Plast Surg       Date:  2014-09       Impact factor: 1.539

5.  Débridement of wounds with Dakin's solution.

Authors: 
Journal:  Arch Surg       Date:  1989-01

6.  [Microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers in a Portuguese hospital].

Authors:  Joana Cabete; F Martins de Carvalho; Luis Moniz; Margarida Pinto; José Neves; Carlos Pereira Alves
Journal:  Rev Port Cir Cardiotorac Vasc       Date:  2011 Jan-Mar

7.  The use of dilute Dakin's solution for the treatment of angioinvasive fungal infection in the combat wounded: a case series.

Authors:  Louis Lewandowski; Richard Purcell; Mark Fleming; Wade T Gordon
Journal:  Mil Med       Date:  2013-04       Impact factor: 1.437

8.  Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics?

Authors:  Alice N Neely; Jason Gardner; Paula Durkee; Glenn D Warden; David G Greenhalgh; James J Gallagher; David N Herndon; Ronald G Tompkins; Richard J Kagan
Journal:  J Burn Care Res       Date:  2009 Jan-Feb       Impact factor: 1.845

Review 9.  Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments.

Authors:  Johan P E Junker; Rami A Kamel; E J Caterson; Elof Eriksson
Journal:  Adv Wound Care (New Rochelle)       Date:  2013-09       Impact factor: 4.730

10.  Fournier's Gangrene: Conventional Dressings versus Dressings with Dakin's Solution.

Authors:  Bülent Altunoluk; Sefa Resim; Erkan Efe; Mustafa Eren; Can Benlioglu; Nazim Kankilic; Halit Baykan
Journal:  ISRN Urol       Date:  2012-03-04
  10 in total
  4 in total

1.  The Continued Utility and Viability of Dakin's Solution in Both High- and Low-resource Settings.

Authors:  Taylor D Ottesen; Rameez A Qudsi; Alexis K Kahanu; Belychagard Jean Baptiste; Pierre Marie Woolley; Adrienne R Socci; George S M Dyer
Journal:  Arch Bone Jt Surg       Date:  2020-03

2.  Dakin's solution in the treatment of severe diabetic foot infections.

Authors:  Bruno Duarte; Ana Formiga; José Neves
Journal:  Int Wound J       Date:  2019-11-12       Impact factor: 3.315

3.  Evaluation of Necrotic, Edematous and Inflammatory Changes in Bone Marrow and Soft Tissue After Irrigation with Different Concentrations of NaOCl Solution: An Experimental Study in Rat Tibia.

Authors:  Kursad Aytekin; Aslihan Duman; Feyza Yildiz Aytekin; Ilkay Cinar; Esra Akdeniz; Selcuk Takir; Cem Zeki Esenyel
Journal:  Eurasian J Med       Date:  2020-06-09

4.  Examination of a first-in-class bis-dialkylnorspermidine-terphenyl antibiotic in topical formulation against mono and polymicrobial biofilms.

Authors:  Mariël Miller; Jeffery C Rogers; Marissa A Badham; Lousili Cadenas; Eian Brightwell; Jacob Adams; Cole Tyler; Paul R Sebahar; Travis J Haussener; Hariprasada Reddy Kanna Reddy; Ryan E Looper; Dustin L Williams
Journal:  PLoS One       Date:  2020-10-19       Impact factor: 3.240

  4 in total

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