Literature DB >> 28197562

N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles.

Battu Harish1, Manyam Subbireddy2, Surisetti Suresh1.   

Abstract

A novel organocatalytic approach, harnessing the unique reactivities of N-heterocyclic carbenes (NHCs), has been revealed for the construction of indoles. The NHC-catalysed atom economical synthesis of a wide range of 2-substituted indole-3-acetic acid derivatives is displayed. Strategic application of the developed method was demonstrated for a short synthesis of a cyclin-dependent kinase (CDK) inhibitor: paullone.

Entities:  

Year:  2017        PMID： 28197562     DOI： 10.1039/c6cc10292a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  N-Heterocyclic carbene (NHC)-catalyzed oxidation of unactivated aldimines to amides via imine umpolung under aerobic conditions.

Authors:  Jakkula Ramarao; Sanjay Yadav; Killari Satyam; Surisetti Suresh
Journal:  RSC Adv       Date:  2022-03-08       Impact factor: 3.361

2.  NHC Catalysis for Umpolung Pyridinium Alkylation via Deoxy-Breslow Intermediates.

Authors:  Terence Wu; Matthew R Tatton; Michael F Greaney
Journal:  Angew Chem Int Ed Engl       Date:  2022-02-18       Impact factor: 16.823
  2 in total

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