Literature DB >> 28197539

Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter.

Veenu Tripathi1, Ying E Zhang1.   

Abstract

Transforming growth factor β (TGF-β) is a well-known growth inhibitor of normal epithelial cells, but it is also secreted by solid tumors to promote cancer progression. Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented by controlling pre-mRNA splicing patterns.

Entities:  

Keywords:  Alternative splicing; EMT; PCBP1; SMAD3; TGF-β; metastasis

Year:  2016        PMID： 28197539      PMCID： PMC5287005          DOI： 10.1080/23723556.2016.1265699

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The Discovery and Early Days of TGF-β: A Historical Perspective.

Authors:  Harold L Moses; Anita B Roberts; Rik Derynck
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-07-01       Impact factor: 10.005

2.  Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β.

Authors:  Veenu Tripathi; Katherine M Sixt; Shaojian Gao; Xuan Xu; Jing Huang; Roberto Weigert; Ming Zhou; Ying E Zhang
Journal:  Mol Cell       Date:  2016-10-13       Impact factor: 17.970

Review 3.  TGFβ signalling in context.

Authors:  Joan Massagué
Journal:  Nat Rev Mol Cell Biol       Date:  2012-09-20       Impact factor: 94.444

Review 4.  Posttranslational Regulation of Smads.

Authors:  Pinglong Xu; Xia Lin; Xin-Hua Feng
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-12-01       Impact factor: 10.005

Review 5.  Regulation of EMT by TGFβ in cancer.

Authors:  Carl-Henrik Heldin; Michael Vanlandewijck; Aristidis Moustakas
Journal:  FEBS Lett       Date:  2012-02-28       Impact factor: 4.124

Review 6.  TGFbeta signalling: a complex web in cancer progression.

Authors:  Hiroaki Ikushima; Kohei Miyazono
Journal:  Nat Rev Cancer       Date:  2010-06       Impact factor: 60.716

Review 7.  Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer.

Authors:  Stephen P Malkoski; Xiao-Jing Wang
Journal:  FEBS Lett       Date:  2012-02-03       Impact factor: 4.124

Review 8.  TGFbeta in Cancer.

Authors:  Joan Massagué
Journal:  Cell       Date:  2008-07-25       Impact factor: 41.582

Review 9.  Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition.

Authors:  Rik Derynck; Baby Periyanayaki Muthusamy; Koy Y Saeteurn
Journal:  Curr Opin Cell Biol       Date:  2014-09-18       Impact factor: 8.382

10.  Non-degradative ubiquitination in Smad-dependent TGF-β signaling.

Authors:  Liu-Ya Tang; Ying E Zhang
Journal:  Cell Biosci       Date:  2011-12-28       Impact factor: 7.133
  10 in total
  2 in total

1.  A TLR/CD44 axis regulates T cell trafficking in experimental and human multiple sclerosis.

Authors:  Maria Tredicine; Chiara Camponeschi; Davide Pirolli; Matteo Lucchini; Mariagrazia Valentini; Maria Concetta Geloso; Massimiliano Mirabella; Marco Fidaleo; Benedetta Righino; Camilla Moliterni; Ezio Giorda; Mario Rende; Maria Cristina De Rosa; Maria Foti; Gabriela Constantin; Francesco Ria; Gabriele Di Sante
Journal:  iScience       Date:  2022-01-11

Review 2.  Transforming growth factor-β in tumour development.

Authors:  Charles B Trelford; Lina Dagnino; Gianni M Di Guglielmo
Journal:  Front Mol Biosci       Date:  2022-10-04
  2 in total

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