Literature DB >> 28197537

Fusion RNA profiling provides hints on cell of origin of mysterious tumor.

Zhongqiu Xie1, Hui Li2.   

Abstract

Biological samples can be grouped into separate clusters based on their gene expression profiles. This approach has yielded meaningful biological insights and facilitated biomarker discoveries. Recently, we developed another approach to study connections between biological samples based on their fusion RNA expression. We have used this approach to provide insights into the cell of origin for a mysterious tumor, alveolar rhabdomyosarcoma.

Entities:  

Keywords:  Alveolar rhabdomyosarcoma; PAX3-FOXO1; fusion RNA; gene fusion; myogenesis

Year:  2016        PMID： 28197537      PMCID： PMC5287003          DOI： 10.1080/23723556.2016.1263714

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Molecular profiling in breast cancer.

Authors:  Shannon R Morris; Lisa A Carey
Journal:  Rev Endocr Metab Disord       Date:  2007-09       Impact factor: 6.514

Review 2.  Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell?

Authors:  Elizabeth Charytonowicz; Carlos Cordon-Cardo; Igor Matushansky; Mel Ziman
Journal:  Cancer Lett       Date:  2008-11-12       Impact factor: 8.679

3.  Muscling in: Uncovering the origins of rhabdomyosarcoma.

Authors:  Simone Hettmer; Amy J Wagers
Journal:  Nat Med       Date:  2010-02       Impact factor: 53.440

4.  Fusion transcriptome profiling provides insights into alveolar rhabdomyosarcoma.

Authors:  Zhongqiu Xie; Mihaela Babiceanu; Shailesh Kumar; Yuemeng Jia; Fujun Qin; Frederic G Barr; Hui Li
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-31       Impact factor: 11.205

5.  Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.

Authors:  Charles Keller; Mark S Hansen; Cheryl M Coffin; Mario R Capecchi
Journal:  Genes Dev       Date:  2004-11-01       Impact factor: 11.361

6.  Molecular portraits of human breast tumours.

Authors:  C M Perou; T Sørlie; M B Eisen; M van de Rijn; S S Jeffrey; C A Rees; J R Pollack; D T Ross; H Johnsen; L A Akslen; O Fluge; A Pergamenschikov; C Williams; S X Zhu; P E Lønning; A L Børresen-Dale; P O Brown; D Botstein
Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

7.  A chimeric RNA characteristic of rhabdomyosarcoma in normal myogenesis process.

Authors:  Huiling Yuan; Fujun Qin; Mercedeh Movassagh; Hong Park; Wendy Golden; Zhongqiu Xie; Peng Zhang; Jeffrey Sklar; Hui Li
Journal:  Cancer Discov       Date:  2013-10-02       Impact factor: 39.397

8.  Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution.

Authors:  F Magrangeas; G Pitiot; S Dubois; E Bragado-Nilsson; M Chérel; S Jobert; B Lebeau; O Boisteau; B Lethé; J Mallet; Y Jacques; S Minvielle
Journal:  J Biol Chem       Date:  1998-06-26       Impact factor: 5.157

9.  Discovery of CTCF-sensitive Cis-spliced fusion RNAs between adjacent genes in human prostate cells.

Authors:  Fujun Qin; Zhenguo Song; Mihaela Babiceanu; Yansu Song; Loryn Facemire; Ritambhara Singh; Mazhar Adli; Hui Li
Journal:  PLoS Genet       Date:  2015-02-06       Impact factor: 5.917

10.  Recurrent chimeric fusion RNAs in non-cancer tissues and cells.

Authors:  Mihaela Babiceanu; Fujun Qin; Zhongqiu Xie; Yuemeng Jia; Kevin Lopez; Nick Janus; Loryn Facemire; Shailesh Kumar; Yuwei Pang; Yanjun Qi; Iulia M Lazar; Hui Li
Journal:  Nucleic Acids Res       Date:  2016-02-02       Impact factor: 16.971
  10 in total
  1 in total

1.  The relationship between chimeric RNAs and gene fusions: Potential implications of reciprocity in cancer.

Authors:  Justin Elfman; Lam-Phong Pham; Hui Li
Journal:  J Genet Genomics       Date:  2020-06-14       Impact factor: 5.723
  1 in total

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