Literature DB >> 28197534

Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer.

M Diefenbacher1, A Orian2.   

Abstract

RNF4, a SUMO-targeted ubiquitin ligase, stabilizes a selected group of oncoproteins. It potentiates oncoprotein activity and serves as a positive feedback agonist of Wnt and Notch pathways. RNF4 is essential for cancer cell survival and its levels are elevated in human cancers, correlating with poor outcome in a subset of cancer patients.

Entities:  

Keywords:  Gene-regulation; RNF4; oncogene; phosphorylation; ubiquitin

Year:  2016        PMID： 28197534      PMCID： PMC5287002          DOI： 10.1080/23723556.2016.1260671

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Degradation of nuclear oncoproteins by the ubiquitin system in vitro.

Authors:  A Ciechanover; J A DiGiuseppe; B Bercovich; A Orian; J D Richter; A L Schwartz; G M Brodeur
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-01       Impact factor: 11.205

Review 2.  SUMO-targeted ubiquitin ligases.

Authors:  Annie M Sriramachandran; R Jürgen Dohmen
Journal:  Biochim Biophys Acta       Date:  2013-09-07

Review 3.  Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.

Authors:  Ryan J Davis; Markus Welcker; Bruce E Clurman
Journal:  Cancer Cell       Date:  2014-10-13       Impact factor: 31.743

Review 4.  The β-catenin destruction complex.

Authors:  Jennifer L Stamos; William I Weis
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-01-01       Impact factor: 10.005

5.  An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.

Authors:  Ching-Ying Kuo; Xu Li; Xiang-Qian Kong; Cheng Luo; Che-Chang Chang; Yiyin Chung; Hsiu-Ming Shih; Keqin Kathy Li; David K Ann
Journal:  J Biol Chem       Date:  2014-06-06       Impact factor: 5.157

6.  Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.

Authors:  Xiaoyan Wang; Melissa Cunningham; Xiaoli Zhang; Sara Tokarz; Bryan Laraway; Megan Troxell; Rosalie C Sears
Journal:  Cancer Res       Date:  2011-01-25       Impact factor: 12.701

7.  Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.

Authors:  Anthony DiBello; Ajit B Datta; Xiangbin Zhang; Cynthia Wolberger
Journal:  J Mol Biol       Date:  2016-09-24       Impact factor: 5.469

Review 8.  Drugging the addict: non-oncogene addiction as a target for cancer therapy.

Authors:  Remco Nagel; Ekaterina A Semenova; Anton Berns
Journal:  EMBO Rep       Date:  2016-10-04       Impact factor: 8.807

9.  Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.

Authors:  Kevin Myant; Xi Qiao; Tuuli Halonen; Christophe Come; Anni Laine; Mahnaz Janghorban; Johanna I Partanen; John Cassidy; Erinn-Lee Ogg; Patrizia Cammareri; Tiina Laiterä; Juha Okkeri; Juha Klefström; Rosalie C Sears; Owen J Sansom; Jukka Westermarck
Journal:  Cell Rep       Date:  2015-07-30       Impact factor: 9.423

10.  RNF4-Dependent Oncogene Activation by Protein Stabilization.

Authors:  Jane J Thomas; Mona Abed; Julian Heuberger; Rostislav Novak; Yaniv Zohar; Angela P Beltran Lopez; Julie S Trausch-Azar; Ma Xenia G Ilagan; David Benhamou; Gunnar Dittmar; Raphael Kopan; Walter Birchmeier; Alan L Schwartz; Amir Orian
Journal:  Cell Rep       Date:  2016-09-20       Impact factor: 9.423
  10 in total
  4 in total

1.  Knockdown of endogenous RNF4 exacerbates ischaemia-induced cardiomyocyte apoptosis in mice.

Authors:  Fang Qiu; Yanna Han; Xiaoqi Shao; Petro Paulo; Wenyue Li; Mengying Zhu; Nannan Tang; Shuaili Guo; Yibing Chen; Han Wu; Dan Zhao; Yu Liu; Wenfeng Chu
Journal:  J Cell Mol Med       Date:  2020-07-28       Impact factor: 5.310

2.  Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway.

Authors:  Cristian Prieto-Garcia; Oliver Hartmann; Michaela Reissland; Thomas Fischer; Carina R Maier; Mathias Rosenfeldt; Christina Schülein-Völk; Kevin Klann; Reinhard Kalb; Ivan Dikic; Christian Münch; Markus E Diefenbacher
Journal:  Cell Death Differ       Date:  2021-10-05       Impact factor: 12.067

3.  RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.

Authors:  Rostislav Novak; Yamen Abu Ahmad; Michael Timaner; Eliya Bitman-Lotan; Avital Oknin-Vaisman; Roi Horwitz; Oliver Hartmann; Michaela Reissland; Viktoria Buck; Mathias Rosenfeldt; David Nikomarov; Markus Elmar Diefenbacher; Yuval Shaked; Amir Orian
Journal:  Cell Death Dis       Date:  2022-09-24       Impact factor: 9.685

Review 4.  SUMO-Targeted Ubiquitin Ligases and Their Functions in Maintaining Genome Stability.

Authors:  Ya-Chu Chang; Marissa K Oram; Anja-Katrin Bielinsky
Journal:  Int J Mol Sci       Date:  2021-05-20       Impact factor: 5.923
  4 in total

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