Literature DB >> 28197531

Targeting SOX9 for degradation to inhibit chemoresistance, metastatic spread, and recurrence.

Aldwin Suryo Rahmanto1, Fredrik J Swartling2, Olle Sangfelt1.   

Abstract

Cancer cells with stem-like properties are believed to contribute to treatment resistance, dissemination, and recurrence. SOX9 controls stem cell plasticity and its deregulation may provide a basis for tumor progression. Here, we summarize our findings of targeted SOX9 destruction by SCFFBW7 (Skp1/Cul1/F-box) in medulloblastoma and its potential for therapeutic intervention.

Entities:  

Keywords:  Drug resistance; FBW7; SCF ubiquitin ligase; SOX9; medulloblastoma; metastasis

Year:  2016        PMID： 28197531      PMCID： PMC5286959          DOI： 10.1080/23723556.2016.1252871

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Slug and Sox9 cooperatively determine the mammary stem cell state.

Authors:  Wenjun Guo; Zuzana Keckesova; Joana Liu Donaher; Tsukasa Shibue; Verena Tischler; Ferenc Reinhardt; Shalev Itzkovitz; Aurelia Noske; Ursina Zürrer-Härdi; George Bell; Wai Leong Tam; Sendurai A Mani; Alexander van Oudenaarden; Robert A Weinberg
Journal:  Cell       Date:  2012-03-02       Impact factor: 41.582

2.  Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.

Authors:  Fredrik J Swartling; Vasil Savov; Anders I Persson; Justin Chen; Christopher S Hackett; Paul A Northcott; Matthew R Grimmer; Jasmine Lau; Louis Chesler; Arie Perry; Joanna J Phillips; Michael D Taylor; William A Weiss
Journal:  Cancer Cell       Date:  2012-05-15       Impact factor: 31.743

3.  Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte.

Authors:  Shinsuke Ohba; Xinjun He; Hironori Hojo; Andrew P McMahon
Journal:  Cell Rep       Date:  2015-07-02       Impact factor: 9.423

4.  Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

Authors:  Srinivas Malladi; Danilo G Macalinao; Xin Jin; Lan He; Harihar Basnet; Yilong Zou; Elisa de Stanchina; Joan Massagué
Journal:  Cell       Date:  2016-03-24       Impact factor: 41.582

5.  Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion.

Authors:  Jean-Christophe Larsimont; Khalil Kass Youssef; Adriana Sánchez-Danés; Vijayakumar Sukumaran; Matthieu Defrance; Benjamin Delatte; Mélanie Liagre; Pieter Baatsen; Jean-Christophe Marine; Saskia Lippens; Christopher Guerin; Véronique Del Marmol; Jean-Marie Vanderwinden; Francois Fuks; Cédric Blanpain
Journal:  Cell Stem Cell       Date:  2015-06-18       Impact factor: 24.633

6.  Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Authors:  Marcel Kool; David T W Jones; Natalie Jäger; Paul A Northcott; Trevor J Pugh; Volker Hovestadt; Rosario M Piro; L Adriana Esparza; Shirley L Markant; Marc Remke; Till Milde; Franck Bourdeaut; Marina Ryzhova; Dominik Sturm; Elke Pfaff; Sebastian Stark; Sonja Hutter; Huriye Seker-Cin; Pascal Johann; Sebastian Bender; Christin Schmidt; Tobias Rausch; David Shih; Jüri Reimand; Laura Sieber; Andrea Wittmann; Linda Linke; Hendrik Witt; Ursula D Weber; Marc Zapatka; Rainer König; Rameen Beroukhim; Guillaume Bergthold; Peter van Sluis; Richard Volckmann; Jan Koster; Rogier Versteeg; Sabine Schmidt; Stephan Wolf; Chris Lawerenz; Cynthia C Bartholomae; Christof von Kalle; Andreas Unterberg; Christel Herold-Mende; Silvia Hofer; Andreas E Kulozik; Andreas von Deimling; Wolfram Scheurlen; Jörg Felsberg; Guido Reifenberger; Martin Hasselblatt; John R Crawford; Gerald A Grant; Nada Jabado; Arie Perry; Cynthia Cowdrey; Sydney Croul; Gelareh Zadeh; Jan O Korbel; Francois Doz; Olivier Delattre; Gary D Bader; Martin G McCabe; V Peter Collins; Mark W Kieran; Yoon-Jae Cho; Scott L Pomeroy; Olaf Witt; Benedikt Brors; Michael D Taylor; Ulrich Schüller; Andrey Korshunov; Roland Eils; Robert J Wechsler-Reya; Peter Lichter; Stefan M Pfister
Journal:  Cancer Cell       Date:  2014-03-17       Impact factor: 31.743

7.  Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.

Authors:  Azadeh Arabi; Karim Ullah; Rui M M Branca; Johan Johansson; Daniel Bandarra; Moritz Haneklaus; Jing Fu; Ingrid Ariës; Peter Nilsson; Monique L Den Boer; Katja Pokrovskaja; Dan Grandér; Gutian Xiao; Sonia Rocha; Janne Lehtiö; Olle Sangfelt
Journal:  Nat Commun       Date:  2012       Impact factor: 14.919

8.  SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma.

Authors:  S Luanpitpong; J Li; A Manke; K Brundage; E Ellis; S L McLaughlin; P Angsutararux; N Chanthra; M Voronkova; Y C Chen; L Wang; P Chanvorachote; M Pei; S Issaragrisil; Y Rojanasakul
Journal:  Oncogene       Date:  2015-09-21       Impact factor: 9.867

9.  FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma.

Authors:  Aldwin Suryo Rahmanto; Vasil Savov; Andrä Brunner; Sara Bolin; Holger Weishaupt; Alena Malyukova; Gabriela Rosén; Matko Čančer; Sonja Hutter; Anders Sundström; Daisuke Kawauchi; David Tw Jones; Charles Spruck; Michael D Taylor; Yoon-Jae Cho; Stefan M Pfister; Marcel Kool; Andrey Korshunov; Fredrik J Swartling; Olle Sangfelt
Journal:  EMBO J       Date:  2016-09-13       Impact factor: 11.598

10.  SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.

Authors:  Xuehui Hong; Wenyu Liu; Ruipeng Song; Jamie J Shah; Xing Feng; Chi Kwan Tsang; Katherine M Morgan; Samuel F Bunting; Hiroyuki Inuzuka; X F Steven Zheng; Zhiyuan Shen; Hatem E Sabaawy; LianXin Liu; Sharon R Pine
Journal:  Nucleic Acids Res       Date:  2016-08-26       Impact factor: 16.971
  10 in total

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