Literature DB >> 28197317

Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines.

Waleed M Hussein1, Saori Mukaida1, Fazren Azmi2, Stacey Bartlett1, Celine Olivier1, Michael R Batzloff3, Michael F Good3, Mariusz Skwarczynski1, Istvan Toth4.   

Abstract

Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund's adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.

Entities:  

Keywords:  Fluorinated lipid; cellular immunity; humoral immunity; nanoparticle; peptide-based vaccine; self-adjuvant

Year:  2017        PMID： 28197317      PMCID： PMC5304309          DOI： 10.1021/acsmedchemlett.6b00453

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  21 in total

Review 1.  Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns.

Authors:  Martin F Bachmann; Gary T Jennings
Journal:  Nat Rev Immunol       Date:  2010-10-15       Impact factor: 53.106

Review 2.  Recent progress in adjuvant discovery for peptide-based subunit vaccines.

Authors:  Fazren Azmi; Abdullah Al Hadi Ahmad Fuaad; Mariusz Skwarczynski; Istvan Toth
Journal:  Hum Vaccin Immunother       Date:  2013-12-03       Impact factor: 3.452

3.  Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers.

Authors:  I-Chun Lin; Mingtao Liang; Tzu-Yu Liu; Zyta M Ziora; Michael J Monteiro; Istvan Toth
Journal:  Biomacromolecules       Date:  2011-03-08       Impact factor: 6.988

Review 4.  Host-pathogen interactions in streptococcal immune sequelae.

Authors:  D Patric Nitsche-Schmitz; Gursharan S Chhatwal
Journal:  Curr Top Microbiol Immunol       Date:  2013       Impact factor: 4.291

5.  Design of three-component vaccines against group A streptococcal infections: importance of spatial arrangement of vaccine components.

Authors:  Abu-Baker M Abdel-Aal; Mehfuz Zaman; Yoshio Fujita; Michael R Batzloff; Michael F Good; Istvan Toth
Journal:  J Med Chem       Date:  2010-10-28       Impact factor: 7.446

6.  Evaluation of Lipopeptides as Toll-like Receptor 2 Ligands.

Authors:  Waleed M Hussein; Phil M Choi; Cheng Zhang; Mei Su; Emma Sierecki; Wayne Johnston; Vincent Fagan; Kirill Alexandrov; Mariusz Skwarczynski; Yann Gambin; Istvan Toth; Pavla Simerska
Journal:  Curr Drug Deliv       Date:  2017       Impact factor: 2.565

Review 7.  The global burden of group A streptococcal diseases.

Authors:  Jonathan R Carapetis; Andrew C Steer; E Kim Mulholland; Martin Weber
Journal:  Lancet Infect Dis       Date:  2005-11       Impact factor: 25.071

8.  Mapping the minimal murine T cell and B cell epitopes within a peptide vaccine candidate from the conserved region of the M protein of group A streptococcus.

Authors:  W A Hayman; E R Brandt; W A Relf; J Cooper; A Saul; M F Good
Journal:  Int Immunol       Date:  1997-11       Impact factor: 4.823

9.  Oil-filled polymer microcapsules for ultrasound-mediated delivery of lipophilic drugs.

Authors:  Klazina Kooiman; Marcel R Böhmer; Marcia Emmer; Hendrik J Vos; Ceciel Chlon; William T Shi; Christopher S Hall; Suzanne H P M de Winter; Karin Schroën; Michel Versluis; Nico de Jong; Annemieke van Wamel
Journal:  J Control Release       Date:  2008-10-09       Impact factor: 9.776

10.  Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus.

Authors:  Nirmal Marasini; Zeinab G Khalil; Ashwini Kumar Giddam; Khairunnisa Abdul Ghaffar; Waleed M Hussein; Robert J Capon; Michael R Batzloff; Michael F Good; Mariusz Skwarczynski; Istvan Toth
Journal:  Int J Pharm       Date:  2016-09-20       Impact factor: 5.875
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  2 in total

Review 1.  Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances.

Authors:  Jiahui Zhang; Jingyi Fan; Mariusz Skwarczynski; Rachel J Stephenson; Istvan Toth; Waleed M Hussein
Journal:  Int J Nanomedicine       Date:  2022-02-25

2.  Rational Design of Antigen Incorporation Into Subunit Vaccine Biomaterials Can Enhance Antigen-Specific Immune Responses.

Authors:  Alexandra N Tsoras; Kong M Wong; Anant K Paravastu; Julie A Champion
Journal:  Front Immunol       Date:  2020-07-21       Impact factor: 7.561
  2 in total

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