Literature DB >> 28197313

From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors.

Jalal Soubhye1, Michel Gelbcke1, Pierre Van Antwerpen1, François Dufrasne1, Mokhtaria Yasmina Boufadi2, Jean Nève1, Paul G Furtmüller3, Christian Obinger3, Karim Zouaoui Boudjeltia4, Franck Meyer5.   

Abstract

The implementation of dynamic combinatorial libraries allowed the determination of highly active reversible and irreversible inhibitors of myeloperoxidase (MPO) at the nanomolar level. Docking experiments highlighted the interaction between the most active ligands and MPO, and further kinetic studies defined the mode of inhibition of these compounds. Finally, in vivo evaluation showed that one dose of irreversible inhibitors is able to suppress the activity of MPO after inducing inflammation.

Entities:  

Keywords:  Myeloperoxidase; dynamic combinatorial chemistry; kinetic study; molecular docking; reversible and irreversible inhibitors

Year:  2016        PMID： 28197313      PMCID： PMC5304337          DOI： 10.1021/acsmedchemlett.6b00417

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  13 in total

Review 1.  Drug discovery by dynamic combinatorial libraries.

Authors:  Olof Ramström; Jean-Marie Lehn
Journal:  Nat Rev Drug Discov       Date:  2002-01       Impact factor: 84.694

Review 2.  Neutrophil interactions with the vascular endothelium.

Authors:  David Dimasi; Wai Y Sun; Claudine S Bonder
Journal:  Int Immunopharmacol       Date:  2013-07-14       Impact factor: 4.932

3.  Inhibition of myeloperoxidase: evaluation of 2H-indazoles and 1H-indazolones.

Authors:  Aaron Roth; Sean Ott; Kelli M Farber; Teresa A Palazzo; Wayne E Conrad; Makhluf J Haddadin; Dean J Tantillo; Carroll E Cross; Jason P Eiserich; Mark J Kurth
Journal:  Bioorg Med Chem       Date:  2014-10-02       Impact factor: 3.641

4.  Characterization of chemical features of potent myeloperoxidase inhibitors.

Authors:  Jalal Soubhye; Franck Meyer; Paul Furtmüller; Christian Obinger; François Dufrasne; Pierre Van Antwerpen
Journal:  Future Med Chem       Date:  2016-07-12       Impact factor: 3.808

5.  Hybrid molecules inhibiting myeloperoxidase activity and serotonin reuptake: a possible new approach of major depressive disorders with inflammatory syndrome.

Authors:  Jalal Soubhye; Iyas Aldib; Martine Prévost; Betina Elfving; Michel Gelbcke; Manuel Podrecca; Raphaël Conotte; Jean-Marie Colet; Paul G Furtmüller; Cédric Delporte; Alexandre Rousseau; Michel Vanhaeverbeek; Jean Nève; Christian Obinger; Karim Zouaoui-Boudjeltia; Pierre Van Antwerpen; François Dufrasne
Journal:  J Pharm Pharmacol       Date:  2014-03-27       Impact factor: 3.765

Review 6.  Myeloperoxidase: friend and foe.

Authors:  Seymour J Klebanoff
Journal:  J Leukoc Biol       Date:  2005-02-02       Impact factor: 4.962

7.  MPO Inhibitors Selected by Virtual Screening.

Authors:  Alberto Malvezzi; Raphael F Queiroz; Leandro de Rezende; Ohara Augusto; Antonia T-do Amaral
Journal:  Mol Inform       Date:  2011-06-28       Impact factor: 3.353

8.  Indomethacin decreases carrageenan-induced peritoneal adhesions.

Authors:  J M DeSimone; M M Meguid; M Kurzer; J Westervelt
Journal:  Surgery       Date:  1988-10       Impact factor: 3.982

Review 9.  Myeloperoxidase: a target for new drug development?

Authors:  E Malle; P G Furtmüller; W Sattler; C Obinger
Journal:  Br J Pharmacol       Date:  2007-06-25       Impact factor: 8.739

10.  Evaluation of new scaffolds of myeloperoxidase inhibitors by rational design combined with high-throughput virtual screening.

Authors:  Iyas Aldib; Jalal Soubhye; Karim Zouaoui Boudjeltia; Michel Vanhaeverbeek; Alexandre Rousseau; Paul G Furtmüller; Christian Obinger; Francois Dufrasne; Jean Nève; Pierre Van Antwerpen; Martine Prévost
Journal:  J Med Chem       Date:  2012-08-07       Impact factor: 7.446
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  5 in total

1.  Inhibition of Myeloperoxidase.

Authors:  Jala Soubhye; Paul G Furtmüller; Francois Dufrasne; Christian Obinger
Journal:  Handb Exp Pharmacol       Date:  2021

2.  Discovery of a Biologically Active Bromodomain Inhibitor by Target-Directed Dynamic Combinatorial Chemistry.

Authors:  Paula García; Victoria L Alonso; Esteban Serra; Andrea M Escalante; Ricardo L E Furlan
Journal:  ACS Med Chem Lett       Date:  2018-09-11       Impact factor: 4.345

Review 3.  Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol.

Authors:  Alwin M Hartman; Robin M Gierse; Anna K H Hirsch
Journal:  European J Org Chem       Date:  2019-05-29

4.  Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase.

Authors:  Lucas Krawczyk; Shubham Semwal; Jalal Soubhye; Salma Lemri Ouadriri; Martin Prévost; Pierre Van Antwerpen; Goedele Roos; Julie Bouckaert
Journal:  Acta Crystallogr D Struct Biol       Date:  2022-08-09       Impact factor: 5.699

5.  Dynamic Covalent Chemistry of Aldehyde Enamines: BiIII - and ScIII -Catalysis of Amine-Enamine Exchange.

Authors:  Yang Zhang; Sheng Xie; Mingdi Yan; Olof Ramström
Journal:  Chemistry       Date:  2017-08-09       Impact factor: 5.236
  5 in total

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