Literature DB >> 28197310

Novel 18F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging.

Ai-Yan Ji1, Qiao-Mei Jin2, Dong-Jian Zhang2, Hua Zhu3, Chang Su1, Xing-Hua Duan1, Li Bian4, Zi-Ping Sun5, Yi-Cheng Ni6, Jian Zhang2, Zhi Yang3, Zhi-Qi Yin7.   

Abstract

Rapid detection and precise evaluation of myocardial viability is necessary to aid in clinical decision making whether to recommend revascularization for patients with myocardial infarction (MI). Three novel 18F-labeled 1-hydroxyanthraquinone derivatives were synthesized, characterized, and evaluated as potential necrosis avid imaging agents for assessment of myocardial viability. Among these tracers, [18F]FA3OP emerged as the most promising compound with best stability and highest targetability. Clear PET images of [18F]FA3OP were obtained in rat model of myocardial infarction and reperfusion at 1 h after injection. In addition, the possible mechanisms of [18F]FA3OP for necrotic myocardium were discussed. The results showed [19F]FA3OP may bind DNA to achieve targetability to necrotic myocardium by intercalation. In summary, [18F]FA3OP was a more promising "hot spot imaging" tracer for rapid visualization of necrotic myocardium.

Entities:  

Keywords:  18F; Myocardial infarction; anthraquinone; necrosis avid agents; positron emission tomography

Year:  2016        PMID： 28197310      PMCID： PMC5304286          DOI： 10.1021/acsmedchemlett.6b00398

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  17 in total

Review 1.  Molecular tracers for the PET and SPECT imaging of disease.

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Review 3.  The advancing clinical impact of molecular imaging in CVD.

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4.  Synthesis and evaluation of novel ¹⁸F labeled 2-pyridinylbenzoxazole and 2-pyridinylbenzothiazole derivatives as ligands for positron emission tomography (PET) imaging of β-amyloid plaques.

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Journal:  J Med Chem       Date:  2012-09-26       Impact factor: 7.446

Review 5.  The current role of infarct avid imaging.

Authors:  B A Khaw
Journal:  Semin Nucl Med       Date:  1999-07       Impact factor: 4.446

6.  Interaction of anticancer drug mitoxantrone with DNA analyzed by electrochemical and spectroscopic methods.

Authors:  Nan Li; Ying Ma; Cheng Yang; Liping Guo; Xiurong Yang
Journal:  Biophys Chem       Date:  2005-08-01       Impact factor: 2.352

7.  Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT.

Authors:  Humphrey Fonge; Kathleen Vunckx; Huaijun Wang; Yuanbo Feng; Luc Mortelmans; Johan Nuyts; Guy Bormans; Alfons Verbruggen; Yicheng Ni
Journal:  Eur Heart J       Date:  2007-12-20       Impact factor: 29.983

8.  Synthesis and evaluation of homo-bivalent GnRHR ligands.

Authors:  Kimberly M Bonger; Richard J B H N van den Berg; Laura H Heitman; Ad P IJzerman; Julia Oosterom; Cornelis M Timmers; Herman S Overkleeft; Gijsbert A van der Marel
Journal:  Bioorg Med Chem       Date:  2007-05-06       Impact factor: 3.641

9.  Targeting extracellular DNA to deliver IGF-1 to the injured heart.

Authors:  Raffay S Khan; Mario D Martinez; Jay C Sy; Karl D Pendergrass; Pao-lin Che; Milton E Brown; E Bernadette Cabigas; Madhuri Dasari; Niren Murthy; Michael E Davis
Journal:  Sci Rep       Date:  2014-03-07       Impact factor: 4.379

10.  Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium.

Authors:  Qin Wang; Shengwei Yang; Cuihua Jiang; Jindian Li; Cong Wang; Linwei Chen; Qiaomei Jin; Shaoli Song; Yuanbo Feng; Yicheng Ni; Jian Zhang; Zhiqi Yin
Journal:  Sci Rep       Date:  2016-02-16       Impact factor: 4.379
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  2 in total

Review 1.  The evolving roles of radiolabeled quinones as small molecular probes in necrotic imaging.

Authors:  Chang Su; Yan Xu
Journal:  Br J Radiol       Date:  2020-05-21       Impact factor: 3.039

2.  Updated developments on molecular imaging and therapeutic strategies directed against necrosis.

Authors:  Dongjian Zhang; Meng Gao; Qiaomei Jin; Yicheng Ni; Jian Zhang
Journal:  Acta Pharm Sin B       Date:  2019-02-13       Impact factor: 11.413
  2 in total

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