Literature DB >> 28197059

Pulmonary Management in Aluminum Phosphide Poisoning.

Ashok Kumar Pannu1.   

Abstract

Entities:  

Year:  2017        PMID: 28197059      PMCID: PMC5278599          DOI: 10.4103/0972-5229.198334

Source DB:  PubMed          Journal:  Indian J Crit Care Med        ISSN: 0972-5229


× No keyword cloud information.
Sir, We read the review article titled, “Thoughts on the current management of acute aluminum phosphide toxicity and proposals for therapy: An evidence-based review” by Farahani et al. with great interest.[1] Authors have well described the new treatment strategies for aluminum phosphide (ALP) poisoning including decontamination, emergency stabilization, and supportive care for cardiovascular, renal, metabolic, and electrolytes abnormalities. Pulmonary complications have also been described in ALP poisoning that requires aggressive support. Acute respiratory distress syndrome (ARDS) can supervene after 6–24 hours, requiring mechanical ventilation support.[23] While the benefit of corticosteroids for ARDS is not established, they might be considered in ALP poisoning as adrenocortical insufficiency is described.[4] Pulmonary aspiration with chemical pneumonitis may occur, and secondary bacterial pneumonia requires antimicrobial therapy. Pulmonary edema may exacerbate circulatory impairment and may require mechanical ventilation and positive end-expiratory pressure (PEEP).[5] It may be noncardiogenic due to direct cytotoxicity and possibly small vessel injury, or there may be a cardiogenic component in some cases. It may manifest with oxygen desaturation, crackles or rales, and occasionally, pink frothy sputum. Bronchodilators should be considered in the presence of bronchospasm with cardiac and electrolyte monitoring as arrhythmia or hypokalemia may be precipitated. Central respiratory depression or ventilatory effort failure is rarely described but might complicate severe poisoning.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.
  3 in total

1.  Adult respiratory distress syndrome following aluminium phosphide ingestion. Report of 4 cases.

Authors:  S N Chugh; S Ram; L K Mehta; B B Arora; K C Malhotra
Journal:  J Assoc Physicians India       Date:  1989-04

2.  Aluminium phosphide poisoning: a prospective study of 16 cases in one year.

Authors:  J S Chopra; O P Kalra; V S Malik; R Sharma; A Chandna
Journal:  Postgrad Med J       Date:  1986-12       Impact factor: 2.401

3.  Adrenocortical involvement in aluminium phosphide poisoning.

Authors:  S N Chugh; S Ram; A Sharma; B B Arora; A S Saini; K C Malhotra
Journal:  Indian J Med Res       Date:  1989-08       Impact factor: 2.375

  3 in total
  2 in total

1.  PGI score: prospective validation and correlation with SOFA, SAPS-II, and APACHE-II scores for predicting outcomes in acute aluminum phosphide poisoning.

Authors:  A K Pannu; L Jhuria; A Bhalla; N Sharma
Journal:  Toxicol Res (Camb)       Date:  2022-04-01       Impact factor: 2.680

2.  Changes of QT Dispersion in Patients Suffering from Aluminium Phosphide Poisoning (Rice Pill).

Authors:  Ali Eshraghi; Niloofar Rajaei; Mahdi Balali Mood; Vida Vakili; Javad Ramezani
Journal:  Open Access Maced J Med Sci       Date:  2019-07-20
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.