Literature DB >> 28196978

Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise and exceed expectations.

Andy Crump1.   

Abstract

Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo's prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co. Incorporated. Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.

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Year:  2017        PMID: 28196978     DOI: 10.1038/ja.2017.11

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  43 in total

Review 1.  The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug.

Authors:  Mandy Juarez; Alejandro Schcolnik-Cabrera; Alfonso Dueñas-Gonzalez
Journal:  Am J Cancer Res       Date:  2018-02-01       Impact factor: 6.166

2.  Ivermectin Impairs the Development of Sexual and Asexual Stages of Plasmodium falciparum In Vitro.

Authors:  Lais Pessanha de Carvalho; Thaisa Lucas Sandri; Edésio José Tenório de Melo; Rolf Fendel; Peter G Kremsner; Benjamin Mordmüller; Jana Held
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

3.  Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine.

Authors:  Na Li; Huanni Li; Ya Wang; Lanqin Cao; Xianquan Zhan
Journal:  EPMA J       Date:  2020-10-10       Impact factor: 6.543

4.  Potential therapeutic effects of Ivermectin in COVID-19.

Authors:  Nastaran Barati; Seyedmousa Motavallihaghi; Banafsheh Nikfar; Shahla Chaichian; Amir Abbas Momtazi-Borojeni
Journal:  Exp Biol Med (Maywood)       Date:  2022-06-10

5.  Identification and Development of Therapeutics for COVID-19.

Authors:  Halie M Rando; Nils Wellhausen; Soumita Ghosh; Alexandra J Lee; Anna Ada Dattoli; Fengling Hu; James Brian Byrd; Diane N Rafizadeh; Ronan Lordan; Yanjun Qi; Yuchen Sun; Christian Brueffer; Jeffrey M Field; Marouen Ben Guebila; Nafisa M Jadavji; Ashwin N Skelly; Bharath Ramsundar; Jinhui Wang; Rishi Raj Goel; YoSon Park; Simina M Boca; Anthony Gitter; Casey S Greene
Journal:  mSystems       Date:  2021-11-02       Impact factor: 6.496

6.  Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases.

Authors:  Honami Yonezawa; Akari Ikeda; Ryo Takahashi; Haruka Endo; Yasuyo Sugawara; Mikako Goto; Mirute Kanno; Sosuke Ogawa; Karin Nakamura; Haruki Ujiie; Masato Iwatsuki; Tomoyasu Hirose; Toshiaki Sunazuka; Yoshimasa Uehara; Naoyuki Nishiya
Journal:  iScience       Date:  2022-03-07

Review 7.  Macrolides: From Toxins to Therapeutics.

Authors:  Kiersten D Lenz; Katja E Klosterman; Harshini Mukundan; Jessica Z Kubicek-Sutherland
Journal:  Toxins (Basel)       Date:  2021-05-12       Impact factor: 4.546

8.  Sorption of selected antiparasitics in soils and sediments.

Authors:  Andre Patrick Heinrich; Timm Zöltzer; Leonard Böhm; Manuel Wohde; Sara Jaddoudi; Yassine El Maataoui; Abdelmalek Dahchour; Rolf-Alexander Düring
Journal:  Environ Sci Eur       Date:  2021-07-02       Impact factor: 5.893

9.  Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study.

Authors:  Suzan M Mansour; Rehab N Shamma; Kawkab A Ahmed; Nirmeen A Sabry; Gamal Esmat; Azza A Mahmoud; Amr Maged
Journal:  Int Immunopharmacol       Date:  2021-07-23       Impact factor: 4.932

10.  Ivermectin and malaria control.

Authors:  Satoshi Ōmura; Andy Crump
Journal:  Malar J       Date:  2017-04-24       Impact factor: 2.979

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