Literature DB >> 28196592

Awakening of "Schlafen11" to Tackle Chemotherapy Resistance in SCLC.

Katrien Berns1, Anton Berns2.   

Abstract

Chemotherapy resistance arises invariably in small cell lung cancer (SCLC). In this issue of Cancer Cell, Gardner et al. find that in some SCLC, EZH2 mediates resistance via downregulation of Schlafen11 (SLFN11). Combining EZH2 inhibition with chemotherapy effectively overcomes drug resistance of xenografted SCLC, holding promise for new treatment paradigms.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28196592     DOI： 10.1016/j.ccell.2017.01.013

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

Review 1.  Targeting DNA damage repair in small cell lung cancer and the biomarker landscape.

Authors:  Triparna Sen; Carl M Gay; Lauren Averett Byers
Journal:  Transl Lung Cancer Res       Date:  2018-02

2.  NRBF2 regulates the chemoresistance of small cell lung cancer by interacting with the P62 protein in the autophagy process.

Authors:  Weitao Shen; Peng Luo; Yueqin Sun; Wei Zhang; Ningning Zhou; Hongrui Zhan; Qingxi Zhang; Jie Shen; Anqi Lin; Quan Cheng; Qiongyao Wang; Jian Zhang; Hai-Hong Wang; Ting Wei
Journal:  iScience       Date:  2022-05-26

Review 3.  Small-cell lung cancer: what we know, what we need to know and the path forward.

Authors:  Adi F Gazdar; Paul A Bunn; John D Minna
Journal:  Nat Rev Cancer       Date:  2017-10-27       Impact factor: 60.716

Review 4.  Polycomb Repressor Complex 2 in Genomic Instability and Cancer.

Authors:  Zoe Veneti; Kalliopi K Gkouskou; Aristides G Eliopoulos
Journal:  Int J Mol Sci       Date:  2017-07-30       Impact factor: 5.923

5.  Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.

Authors:  Shuhui Zhang; Lin Zhou; Mengdi Zhang; Yuehua Wang; Mengqi Wang; Jincheng Du; Wenwen Gu; Fuguang Kui; Jiahuan Li; Shengnan Geng; Gangjun Du
Journal:  Front Pharmacol       Date:  2020-01-29       Impact factor: 5.810

6.  mRNA Network: Solution for Tracking Chemotherapy Insensitivity in Small-Cell Lung Cancer.

Authors:  Peixin Chen; Shengyu Wu; Jia Yu; Xuzhen Tang; Chunlei Dai; Hui Qi; Junjie Zhu; Wei Li; Bin Chen; Jun Zhu; Hao Wang; Sha Zhao; Hongcheng Liu; Peng Kuang; Yayi He
Journal:  J Healthc Eng       Date:  2021-09-28       Impact factor: 2.682

Review 7.  Absence of Biomarker-Driven Treatment Options in Small Cell Lung Cancer, and Selected Preclinical Candidates for Next Generation Combination Therapies.

Authors:  Nicholas R Liguori; Young Lee; William Borges; Lanlan Zhou; Christopher Azzoli; Wafik S El-Deiry
Journal:  Front Pharmacol       Date:  2021-08-31       Impact factor: 5.810

8.  Study of Clinical Predictive Value and Immune Characterization of SLFN11 in Clear Cell Renal Cell Carcinoma.

Authors:  Yifu Liu; Zhicheng Zhang; Shengqiang Fu; Siyuan Wang; Xiaofeng Cheng; Kunyang Lei; Zhilong Li; Ting Sun; Ming Ma
Journal:  Int J Gen Med       Date:  2021-10-13

9.  Awakening of SCHLAFEN 11 by immunohistochemistry: a new biomarker predicting response to chemotherapy.

Authors:  Reinhard Buettner
Journal:  Virchows Arch       Date:  2021-03       Impact factor: 4.064
  9 in total

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