Literature DB >> 28196591

Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis.

Martin J Baker1, Mariana Cooke1, Marcelo G Kazanietz2.   

Abstract

The RhoGEF Ect2 controls cell division and exerts oncogenic functions in multiple cancers. In this issue of Cancer Cell, Justilien et al. report that Ect2 is required for lung tumorigenesis and identified a role for this GEF in ribosomal RNA (rRNA) synthesis that is mediated by Rac1 and PKCι-dependent phosphorylation.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28196591     DOI： 10.1016/j.ccell.2017.01.008

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  8 in total

Review 1.  The Rac GTPase in Cancer: From Old Concepts to New Paradigms.

Authors:  Marcelo G Kazanietz; Maria J Caloca
Journal:  Cancer Res       Date:  2017-08-14       Impact factor: 12.701

Review 2.  The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic.

Authors:  Victoria Casado-Medrano; Martin J Baker; Cynthia Lopez-Haber; Mariana Cooke; Shaofei Wang; Maria J Caloca; Marcelo G Kazanietz
Journal:  Biochem Soc Trans       Date:  2018-07-31       Impact factor: 5.407

Review 3.  Shared mechanisms regulate spatiotemporal RhoA-dependent actomyosin contractility during adhesion and cell division.

Authors:  Patrick W B Derksen; Robert A H van de Ven
Journal:  Small GTPases       Date:  2017-12-31

4.  PKCε regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells.

Authors:  Mariana Cooke; Martin J Baker; Marcelo G Kazanietz; Victoria Casado-Medrano
Journal:  Small GTPases       Date:  2019-10-29

5.  CircRIP2 promotes NSCLC progression by sponging for miR-671-5p to regulate FOXM1 expression.

Authors:  Yizhi Liu; Xing Feng; Shuhong Kang; Feng Lv; Yunfeng Ni; Hua Wu
Journal:  Histol Histopathol       Date:  2021-07-22       Impact factor: 2.303

6.  Modulation of alternative splicing induced by paclitaxel in human lung cancer.

Authors:  Ziran Zhu; Dan Chen; Wenjing Zhang; Jinyao Zhao; Lili Zhi; Fang Huang; Haoyu Ji; Jinrui Zhang; Han Liu; Lijuan Zou; Yang Wang
Journal:  Cell Death Dis       Date:  2018-05-01       Impact factor: 8.469

7.  RAC2 acts as a prognostic biomarker and promotes the progression of clear cell renal cell carcinoma.

Authors:  Yuenan Liu; Gong Cheng; Zhengshuai Song; Tianbo Xu; Hailong Ruan; Qi Cao; Keshan Wang; Lin Bao; Jingchong Liu; Lijie Zhou; Di Liu; Hongmei Yang; Ke Chen; Xiaoping Zhang
Journal:  Int J Oncol       Date:  2019-07-26       Impact factor: 5.650

8.  P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer.

Authors:  Martin J Baker; Martín C Abba; Rafael Garcia-Mata; Marcelo G Kazanietz
Journal:  Cancers (Basel)       Date:  2020-02-19       Impact factor: 6.639
  8 in total

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