Erika Kuwahara1, Yoshitaka Murakami2, Tomonori Okamura3, Hirokazu Komatsu4, Akemi Nakazawa5, Hideo Ushiku6, Fumio Maejima5, Yoshio Nishigaki5, Yuji Nishiwaki1. 1. Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan. 2. Department of Medical Statistics, School of Medicine, Toho University, Tokyo, Japan. 3. Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan. 4. Department of Community Care, Saku Central Hospital, Nagano, Japan. 5. Division of Health Care, Saku Central Hospital, Nagano, Japan. 6. Department of Pediatrics, Saku Central Hospital, Nagano, Japan.
Abstract
BACKGROUND: Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan. METHODS: We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6-12 y of age). The association between the three DBMI groups and SUA in adults was analyzed. RESULTS: The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group. CONCLUSION: Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk.
BACKGROUND: Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan. METHODS: We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6-12 y of age). The association between the three DBMI groups and SUA in adults was analyzed. RESULTS: The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group. CONCLUSION: Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk.