| Literature DB >> 28194849 |
Feng Zhao1, Nan Li1, Tao Zhang1, Zhi-Yong Han1, Shi-Wei Luo1, Liu-Zhu Gong1,2.
Abstract
Carbophilic gold carbenes generated from the decomposition of α-diazoesters show high reactivity towards enamides, leading to an unprecedented aza-ene-type reaction. The presence of 0.1 mol % of a chiral Brønsted acid co-catalyst is sufficient to give synthetically relevant γ-keto esters in excellent yields and selectivities (up to 99 % yield, 97 % ee).Entities:
Keywords: Brønsted acids; asymmetric protonation; aza-ene reactions; gold carbenes; relay catalysis
Year: 2017 PMID： 28194849 DOI： 10.1002/anie.201612208
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336