Yuanyuan Wang1, Xingcun Zhang1, Yadong Yang1, Junbo Zhang1, Yunchuan Yang1, Yuangang Lu2. 1. Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, People's Republic of China. 2. Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, People's Republic of China. 11794643@qq.com.
Abstract
OBJECTIVE: To evaluate the efficacy and safety of 2% topical propranolol cream in the treatment of proliferating infantile strawberry hemangiomas. METHODS: A total of 40 infants were enrolled; 2% propranolol cream was applied three times daily. In the subsequent monthly visit, dynamic changes in tumor size, texture, and color were recorded. The adverse events (AEs) were observed. Treatment outcomes were scored on a four-point scale. All patients were followed up for 12 mo after treatment. RESULTS: The overall response was graded Scale 1 (poor response) in 2 patients, Scale 2 (moderate response) in 15 patients, Scale 3 (good response) in 17 patients, and Scale 4 (excellent response) in 6 patients. No significant differences were seen in treatment outcomes between female and male patients, among lesion locations/size, or in the age at the start of the treatment. No obvious AEs were reported. CONCLUSIONS: 2% topical propranolol cream is safe and effective for the treatment of proliferating infantile strawberry hemangiomas.
OBJECTIVE: To evaluate the efficacy and safety of 2% topical propranolol cream in the treatment of proliferating infantile strawberry hemangiomas. METHODS: A total of 40 infants were enrolled; 2% propranolol cream was applied three times daily. In the subsequent monthly visit, dynamic changes in tumor size, texture, and color were recorded. The adverse events (AEs) were observed. Treatment outcomes were scored on a four-point scale. All patients were followed up for 12 mo after treatment. RESULTS: The overall response was graded Scale 1 (poor response) in 2 patients, Scale 2 (moderate response) in 15 patients, Scale 3 (good response) in 17 patients, and Scale 4 (excellent response) in 6 patients. No significant differences were seen in treatment outcomes between female and male patients, among lesion locations/size, or in the age at the start of the treatment. No obvious AEs were reported. CONCLUSIONS: 2% topical propranolol cream is safe and effective for the treatment of proliferating infantile strawberry hemangiomas.
Authors: Christine Léauté-Labrèze; Eric Dumas de la Roque; Thomas Hubiche; Franck Boralevi; Jean-Benoît Thambo; Alain Taïeb Journal: N Engl J Med Date: 2008-06-12 Impact factor: 91.245
Authors: Juliette Mazereeuw-Hautier; Peter H Hoeger; Sarah Benlahrech; Amir Ammour; Pierre Broue; Julie Vial; Gerard Ohanessian; Christine Léauté-Labrèze; Marc Labenne; Pierre Vabres; Jochen Rössler; Christine Bodemer Journal: J Pediatr Date: 2010-05-20 Impact factor: 4.406
Authors: Cherise Es Tan; Tinte Itinteang; Philip Leadbitter; Reginald Marsh; Swee T Tan Journal: J Paediatr Child Health Date: 2014-09-03 Impact factor: 1.954
Authors: Anita N Haggstrom; Beth A Drolet; Eulalia Baselga; Sarah L Chamlin; Maria C Garzon; Kimberly A Horii; Anne W Lucky; Anthony J Mancini; Denise W Metry; Brandon Newell; Amy J Nopper; Ilona J Frieden Journal: Pediatrics Date: 2006-09 Impact factor: 7.124
Authors: Laura Macca; Domenica Altavilla; Luca Di Bartolomeo; Natasha Irrera; Francesco Borgia; Federica Li Pomi; Federico Vaccaro; Violetta Squadrito; Francesco Squadrito; Mario Vaccaro Journal: Front Pharmacol Date: 2022-05-26 Impact factor: 5.988