Literature DB >> 28194541

Undermining plastic surgery as a possible option for treating basal cell carcinoma of the forehead.

Georgi Tchernev1,2, Ivan Pidakev3, Ilia Lozev3, Torello Lotti4, Jose Carlos Cardoso5, James W Patterson6.   

Abstract

Basal cell carcinoma (BCC) is the most common cutaneous cancer. Although most cases can be cured with simple surgical procedures and are associated with a good prognosis, a minority of BCCs may pose significant therapeutic challenges. This occurs mostly in cases of so-called advanced BCC, which a loosely defined term that encompasses locally advanced lesions and tumors with metastatic spread. Treatment of these cases is often complex and sometimes may need combinations of therapeutic modalities, including surgery, radiotherapy and/or targeted therapy directed towards sonic hedgehog (SHH) signaling pathways, such as vismodegib. We herein present the case of a 74-year-old man presenting with a large basal cell of the forehead evolving for more than 7 years. The patient underwent excision of the lesion with clear surgical margins. Reconstruction of the defect was performed after extensive undermining of the skin allowing subsequent direct closure with a simple suture, which resulted in an acceptable cosmetic outcome. We discuss the potential advantages, disadvantages, and applicability of this relatively simple surgical maneuver in the reconstruction of defects resulting from excision of considerably large cutaneous tumors.

Entities:  

Keywords:  BCC; Outcome; Skin cancer; Surgery; Treatment

Mesh:

Year:  2017        PMID: 28194541     DOI: 10.1007/s10354-017-0542-x

Source DB:  PubMed          Journal:  Wien Med Wochenschr        ISSN: 0043-5341


  4 in total

1.  Relapsing advanced metatypical basal cell carcinomas (MTBCC) of the face: surgical modalities.

Authors:  Georgi Tchernev; Anastasiya Atanasova Chokoeva; Plamen Kolev Penev; Julian Ananiev; Andreas Nowak; Yousef Bayyoud; Stanislav Philipov; José-Carlos Cardoso; Uwe Wollina
Journal:  Wien Med Wochenschr       Date:  2014-10-02

2.  Failure of vismodegib in advanced Basal cell carcinoma.

Authors:  G Hansel; G Tchernev; A A Chokoeva; T Lotti; J Schönlebe; U Wollina
Journal:  J Biol Regul Homeost Agents       Date:  2015 Jan-Mar       Impact factor: 1.711

Review 3.  Advanced basal cell carcinoma.

Authors:  Uwe Wollina; Georgi Tchernev
Journal:  Wien Med Wochenschr       Date:  2013-04-16

Review 4.  Advanced Basal Cell Carcinoma: Epidemiology and Therapeutic Innovations.

Authors:  Shalini V Mohan; Anne Lynn S Chang
Journal:  Curr Dermatol Rep       Date:  2014-02-09
  4 in total
  2 in total

1.  Basal Cell Carcinoma Surgery: Simple Undermining Approach in Two Patients with Different Tumour Locations.

Authors:  Georgi Tchernev; Cristiana Voicu; Mara Mihai; Mihai Lupu; Tiberiu Tebeica; Nely Koleva; Uwe Wollina; Torello Lotti; Hristo Mangarov; Ilko Bakardzhiev; Jacopo Lotti; Katlein França; Atanas Batashki; James W Patterson
Journal:  Open Access Maced J Med Sci       Date:  2017-07-24

2.  Comparative Analysis of the Applicability of Island Flap in Primary and Recurrent Basal Cell Carcinomas of Similar Localization.

Authors:  Georgi Tchernev; Ivanka Temelkova; Hristo Mangarov; Konstantin Stavrov
Journal:  Open Access Maced J Med Sci       Date:  2018-06-06
  2 in total

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