Literature DB >> 28193856

Contribution of epigenetic mechanisms to variation in cancer risk among tissues.

Michael Klutstein1, Joshua Moss2,3, Tommy Kaplan3, Howard Cedar4.   

Abstract

Recently, it was suggested that tissue variation in cancer risk originates from differences in the number of stem-cell divisions underlying each tissue, leading to different mutation loads. We show that this variation is also correlated with the degree of aberrant CpG island DNA methylation in normal cells. Methylation accumulates during aging in a subset of molecules, suggesting that the epigenetic landscape within a founder-cell population may contribute to tumor formation.

Entities:  

Keywords:  aging; methylation; polycomb

Mesh：

Year:  2017        PMID： 28193856      PMCID： PMC5338490          DOI： 10.1073/pnas.1616556114

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.

Authors:  Michael T McCabe; Jonathan A Low; Stephanie Daignault; Michael J Imperiale; Kirk J Wojno; Mark L Day
Journal:  Cancer Res       Date:  2006-01-01       Impact factor: 12.701

2.  Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.

Authors:  Yasuhiro Yamada; Laurie Jackson-Grusby; Heinz Linhart; Alex Meissner; Amir Eden; Haijiang Lin; Rudolf Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-08       Impact factor: 11.205

Review 3.  Decitabine, a new star in epigenetic therapy: the clinical application and biological mechanism in solid tumors.

Authors:  Jing Nie; Lin Liu; Xiang Li; Weidong Han
Journal:  Cancer Lett       Date:  2014-08-14       Impact factor: 8.679

4.  The Polycomb group protein EZH2 directly controls DNA methylation.

Authors:  Emmanuelle Viré; Carmen Brenner; Rachel Deplus; Loïc Blanchon; Mario Fraga; Céline Didelot; Lluis Morey; Aleyde Van Eynde; David Bernard; Jean-Marie Vanderwinden; Mathieu Bollen; Manel Esteller; Luciano Di Croce; Yvan de Launoit; François Fuks
Journal:  Nature       Date:  2005-12-14       Impact factor: 49.962

Review 5.  Decitabine: a promising epi-immunotherapeutic agent in solid tumors.

Authors:  Xiang Li; Qian Mei; Jing Nie; Xiaobing Fu; Weidong Han
Journal:  Expert Rev Clin Immunol       Date:  2015-01-12       Impact factor: 4.473

Review 6.  Inferring human stem cell behaviour from epigenetic drift.

Authors:  D Shibata
Journal:  J Pathol       Date:  2009-01       Impact factor: 7.996

7.  Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.

Authors:  Deqiang Sun; Min Luo; Mira Jeong; Benjamin Rodriguez; Zheng Xia; Rebecca Hannah; Hui Wang; Thuc Le; Kym F Faull; Rui Chen; Hongcang Gu; Christoph Bock; Alexander Meissner; Berthold Göttgens; Gretchen J Darlington; Wei Li; Margaret A Goodell
Journal:  Cell Stem Cell       Date:  2014-05-01       Impact factor: 24.633

8.  Epigenetic changes in cancer.

Authors:  Manel Esteller
Journal:  F1000 Biol Rep       Date:  2011-05-03

9.  Age-related epigenetic drift in the pathogenesis of MDS and AML.

Authors:  Shinji Maegawa; Sheryl M Gough; Naoko Watanabe-Okochi; Yue Lu; Nianxiang Zhang; Ryan J Castoro; Marcos R H Estecio; Jaroslav Jelinek; Shoudan Liang; Toshio Kitamura; Peter D Aplan; Jean-Pierre J Issa
Journal:  Genome Res       Date:  2014-01-10       Impact factor: 9.043

10.  Hematopoietic stem and progenitor cells acquire distinct DNA-hypermethylation during in vitro culture.

Authors:  Carola Ingrid Weidner; Thomas Walenda; Qiong Lin; Monika Martina Wölfler; Bernd Denecke; Ivan Gesteira Costa; Martin Zenke; Wolfgang Wagner
Journal:  Sci Rep       Date:  2013-11-28       Impact factor: 4.379
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  19 in total

Review 1.  Epigenetic Aging: More Than Just a Clock When It Comes to Cancer.

Authors:  Ming Yu; William M Grady; William D Hazelton; Georg E Luebeck
Journal:  Cancer Res       Date:  2019-11-06       Impact factor: 12.701

Review 2.  Epigenome-based cancer risk prediction: rationale, opportunities and challenges.

Authors:  Martin Widschwendter; Allison Jones; Iona Evans; Daniel Reisel; Joakim Dillner; Karin Sundström; Ewout W Steyerberg; Yvonne Vergouwe; Odette Wegwarth; Felix G Rebitschek; Uwe Siebert; Gaby Sroczynski; Inez D de Beaufort; Ineke Bolt; David Cibula; Michal Zikan; Line Bjørge; Nicoletta Colombo; Nadia Harbeck; Frank Dudbridge; Anne-Marie Tasse; Bartha M Knoppers; Yann Joly; Andrew E Teschendorff; Nora Pashayan
Journal:  Nat Rev Clin Oncol       Date:  2018-02-27       Impact factor: 66.675

3.  DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk.

Authors:  Wenbing Xie; Ioannis Kagiampakis; Lixia Pan; Yang W Zhang; Lauren Murphy; Yong Tao; Xiangqian Kong; Byunghak Kang; Limin Xia; Filipe L F Carvalho; Subhojit Sen; Ray-Whay Chiu Yen; Cynthia A Zahnow; Nita Ahuja; Stephen B Baylin; Hariharan Easwaran
Journal:  Cancer Cell       Date:  2018-02-12       Impact factor: 31.743

4.  Models of epigenetic age capture patterns of DNA methylation in glioma associated with molecular subtype, survival, and recurrence.

Authors:  Peter Liao; Quinn T Ostrom; Lindsay Stetson; Jill S Barnholtz-Sloan
Journal:  Neuro Oncol       Date:  2018-06-18       Impact factor: 12.300

5.  O6-Methylguanine-DNA Methyltransferase and ATP-Binding Cassette Membrane Transporter G2 Promotor Methylation: Can Predict the Response to Chemotherapy in Advanced Breast Cancer?

Authors:  Sara Ahmed Aglan; Ahmad Mohamad Zaki; Amel Sobhy El Sedfy; Heba Gaber El-Sheredy; Ola Hussein Elgaddar
Journal:  Rep Biochem Mol Biol       Date:  2022-04

Review 6.  Making sense of the ageing methylome.

Authors:  Kirsten Seale; Steve Horvath; Andrew Teschendorff; Nir Eynon; Sarah Voisin
Journal:  Nat Rev Genet       Date:  2022-05-02       Impact factor: 59.581

Review 7.  Aging and cancer epigenetics: Where do the paths fork?

Authors:  Raúl Fernández Pérez; Juan Ramón Tejedor; Agustín Fernández Fernández; Mario Fernández Fraga
Journal:  Aging Cell       Date:  2022-09-14       Impact factor: 11.005

8.  Tissue-specific DNA methylation loss during ageing and carcinogenesis is linked to chromosome structure, replication timing and cell division rates.

Authors:  Marija Dmitrijeva; Stephan Ossowski; Luis Serrano; Martin H Schaefer
Journal:  Nucleic Acids Res       Date:  2018-08-21       Impact factor: 16.971

Review 9.  Cancer-Associated Mutations but No Cancer: Insights into the Early Steps of Carcinogenesis and Implications for Early Cancer Detection.

Authors:  Scott R Kennedy; Yuezheng Zhang; Rosa Ana Risques
Journal:  Trends Cancer       Date:  2019-08-22

10.  Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing.

Authors:  Stephany Orjuela; Hannah R Parker; Sija Sajibu; Fabrizio Cereatti; Matthias Sauter; Federico Buffoli; Mark D Robinson; Giancarlo Marra
Journal:  Epigenetics       Date:  2021-08-09       Impact factor: 4.861
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