Nayere Askari1, Tooba Ghazanfari2, Roya Yaraee2, Mohammad Reza Vaez Mahdavi2, Mohammad-Reza Soroush3, Zuhair Mohammad Hassan4, Zohre Khodashenas5, Jalaleddin Shams2, Soghrat Faghihzadeh6. 1. Department of Biology, Faculty of Basic Sciences, Shahid Bahonar, University of Kerman, Kerman, I.R. Iran. 2. Immunoregulation Research Center, Shahed University, Tehran, I.R. Iran. 3. Janbazan Medical and Engineering Research Center (JMERC), Tehran, I.R. Iran. 4. Department of Immunology, Tarbiat Moddares University, Tehran, I.R. Iran. 5. Department of Dermatology, Tehran University Medical Sciences, Tehran, I.R. Iran. 6. Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, I.R. Iran.
Abstract
BACKGROUND: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals. METHODS: Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique. RESULTS: The median of serum levels of IL-1β, IL-8 and RANTES were significantly higher in the exposed patients with acne than those without acne (P = 0.05, 0.03 and 0.001 respectively). There was no significant difference in serum levels of IL-1α, IL-1Ra and IL-6 between the exposed subgroups. CONCLUSION: We found a positive association between serum levels of pro-inflammatory cytokines (IL-1β, IL-8, IL-12 and RANTES) and acne among SM-exposed population.
BACKGROUND:Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals. METHODS: Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique. RESULTS: The median of serum levels of IL-1β, IL-8 and RANTES were significantly higher in the exposed patients with acne than those without acne (P = 0.05, 0.03 and 0.001 respectively). There was no significant difference in serum levels of IL-1α, IL-1Ra and IL-6 between the exposed subgroups. CONCLUSION: We found a positive association between serum levels of pro-inflammatory cytokines (IL-1β, IL-8, IL-12 and RANTES) and acne among SM-exposed population.