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Literature DB >> 28191925

Mechanistic Debris Generated by Twister Ribozymes.

Abstract

Twister RNAs represent a recently discovered class of natural ribozymes that promote rapid cleaving of RNA backbones. Although an abundance of theoretical, biochemical, and structural data exist for several members of the twister class, disagreements about the architecture and mechanism of its active site have emerged. Historically, such storms regarding mechanistic details typically occur soon after each new self-cleaving ribozyme class is reported, but paths forward exist to quickly reach calmer conditions.

Entities: Chemical

Mesh：

Substances：
RNA, Catalytic

Year: 2017 PMID： 28191925 PMCID： PMC5778351 DOI： 10.1021/acschembio.7b00010

Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100

26 in total

1. Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis.

Authors: P B Rupert; A R Ferré-D'Amaré
Journal: Nature Date: 2001-04-12 Impact factor: 49.962

Review 2. Ribozyme speed limits.

Authors: Gail Mitchell Emilsson; Shingo Nakamura; Adam Roth; Ronald R Breaker
Journal: RNA Date: 2003-08 Impact factor: 4.942

3. A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.

Authors: Marija Košutić; Sandro Neuner; Aiming Ren; Sara Flür; Christoph Wunderlich; Elisabeth Mairhofer; Nikola Vušurović; Jan Seikowski; Kathrin Breuker; Claudia Höbartner; Dinshaw J Patel; Christoph Kreutz; Ronald Micura
Journal: Angew Chem Int Ed Engl Date: 2015-10-16 Impact factor: 15.336

Mechanistic Debris Generated by Twister Ribozymes.

1. Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis.

Review 2. Ribozyme speed limits.

3. A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.

Review 4. Chemistry and Biology of Self-Cleaving Ribozymes.

5. The Novel Chemical Mechanism of the Twister Ribozyme.

6. In-line alignment and Mg²⁺ coordination at the cleavage site of the env22 twister ribozyme.

7. Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.

8. The structure of a nucleolytic ribozyme that employs a catalytic metal ion.

9. A widespread self-cleaving ribozyme class is revealed by bioinformatics.

10. Biochemical analysis of hatchet self-cleaving ribozymes.

1. Cleaning Up Mechanistic Debris Generated by Twister Ribozymes Using Computational RNA Enzymology.

2. Small Molecule Rescue and Glycosidic Conformational Analysis of the Twister Ribozyme.

3. Mg²⁺ Impacts the Twister Ribozyme through Push-Pull Stabilization of Nonsequential Phosphate Pairs.

4. An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes.

Review 5. Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes.

6. Model for the Functional Active State of the TS Ribozyme from Molecular Simulation.

7. Cellular Small Molecules Contribute to Twister Ribozyme Catalysis.

8. Pseudoknot Formation Seeds the Twister Ribozyme Cleavage Reaction Coordinate.

9. Imaginary Ribozymes.

Review 10. A guide to large-scale RNA sample preparation.