Literature DB >> 28191367

Composite Diffuse Large B-cell and Mantle Cell Lymphoma: A Case Report.

Farhan Mohammad1, Gwenalyn Garcia1, Shiksha Kedia1, Juan Ding2, Matthew Hurford2, Alexander Bershadskiy1.   

Abstract

Composite lymphoma is an extremely rare clinical entity and is characterized by the presence of two different subtypes of lymphoma in the same lymph node. We report a case of composite lymphoma in a 57-year-old male presenting with leg and groin pain. The right inguinal lymph node biopsy showed large and small cells. Immunohistochemistry was consistent with large cells staining for diffuse large B-cell lymphoma (DLBCL) and small cells positive for mantle cell lymphoma (MCL). Polymerase chain reaction (PCR) analysis of immunoglobulin heavy (IGH) chain and immunoglobulin kappa (IGK) light chain gene rearrangements confirmed that the two were clonally unrelated neoplasms. There are only two reported cases of composite lymphoma with this combination in the published English literature. We report the third such case and discuss the pathology, diagnostic challenges and management of composite lymphoma.

Entities:  

Keywords:  composite; lymphoma; r-chop

Year:  2017        PMID： 28191367      PMCID： PMC5298913          DOI： 10.7759/cureus.963

Source DB:  PubMed          Journal:  Cureus        ISSN： 2168-8184


  8 in total

1.  Composite mantle cell and diffuse large B-cell lymphoma: report of two cases.

Authors:  Albert K Ho; Carolin J Teman; Gregory P Smith; Daniel R Nightingale; Rodney R Miles
Journal:  Int J Surg Pathol       Date:  2011-10       Impact factor: 1.271

2.  Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases.

Authors:  Endi Wang; Paulie Papavassiliou; Alun R Wang; Abner Louissaint; Jun Wang; Charles Blake Hutchinson; Qin Huang; Deepti Reddi; Qiang Wei; Siby Sebastian; Catherine Rehder; Russell Brynes; Imran Siddiqi
Journal:  Hum Pathol       Date:  2013-11-26       Impact factor: 3.466

Review 3.  Mantle cell lymphoma: evolving management strategies.

Authors:  Elias Campo; Simon Rule
Journal:  Blood       Date:  2014-12-11       Impact factor: 22.113

Review 4.  Mantle Cell Lymphoma.

Authors:  Chan Yoon Cheah; John F Seymour; Michael L Wang
Journal:  J Clin Oncol       Date:  2016-01-11       Impact factor: 44.544

Review 5.  Pathogenesis, diagnosis, and treatment of composite lymphomas.

Authors:  Ralf Küppers; Ulrich Dührsen; Martin-Leo Hansmann
Journal:  Lancet Oncol       Date:  2014-09       Impact factor: 41.316

Review 6.  Composite lymphoma and related disorders.

Authors:  H Kim
Journal:  Am J Clin Pathol       Date:  1993-04       Impact factor: 2.493

7.  Non-Hodgkin lymphoma subtype distribution, geodemographic patterns, and survival in the US: A longitudinal analysis of the National Cancer Data Base from 1998 to 2011.

Authors:  Mohammed Al-Hamadani; Thomas M Habermann; James R Cerhan; William R Macon; Matthew J Maurer; Ronald S Go
Journal:  Am J Hematol       Date:  2015-07-27       Impact factor: 10.047

8.  Primary Pulmonary Lymphoma and Synchronous Cecal Adenocarcinoma: A Rare Occurrence.

Authors:  Amina Saqib; Uroosa Ibrahim; Rabih Maroun
Journal:  Cureus       Date:  2016-12-27
  8 in total
  1 in total

1.  Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case report.

Authors:  Asil Esper; Sami Alhoulaiby; Ruba Zuhri Yafi; Zuheir Alshehabi
Journal:  J Med Case Rep       Date:  2021-04-14
  1 in total

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