Anita Aminoshariae1, James C Kulild2, Andre Mickel2, Ashraf F Fouad3. 1. Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio. Electronic address: aaminoshariae@yahoo.com. 2. Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio. 3. Department of Endodontics, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina.
Abstract
INTRODUCTION: To date, the relationships between systemic diseases and endodontic treatment outcomes remain poorly studied. Thus, the purpose of this systematic review was to evaluate the relationship between host-modifying factors and their association with endodontic outcomes. METHODS: Two reviewers independently conducted a comprehensive literature search. The MEDLINE, Embase, Cochrane, and PubMed databases were searched. In addition, the bibliographies and gray literature of all relevant articles and textbooks were manually searched. There was no disagreement between the 2 reviewers. RESULTS: Sixteen articles met the inclusion criteria with moderate to high risk of bias. There was no article with low risk of bias. Available scientific evidence remains inconclusive as to whether diabetes and/or cardiovascular disease(s) may be associated with endodontic outcomes. Human immunodeficiency virus and oral bisphosphonate did not appear to be associated with endodontic outcomes. CONCLUSIONS: Although additional well-designed longitudinal clinical studies are needed, the results of this systematic review suggest that some systemic diseases may be correlated with endodontic outcomes.
INTRODUCTION: To date, the relationships between systemic diseases and endodontic treatment outcomes remain poorly studied. Thus, the purpose of this systematic review was to evaluate the relationship between host-modifying factors and their association with endodontic outcomes. METHODS: Two reviewers independently conducted a comprehensive literature search. The MEDLINE, Embase, Cochrane, and PubMed databases were searched. In addition, the bibliographies and gray literature of all relevant articles and textbooks were manually searched. There was no disagreement between the 2 reviewers. RESULTS: Sixteen articles met the inclusion criteria with moderate to high risk of bias. There was no article with low risk of bias. Available scientific evidence remains inconclusive as to whether diabetes and/or cardiovascular disease(s) may be associated with endodontic outcomes. Human immunodeficiency virus and oral bisphosphonate did not appear to be associated with endodontic outcomes. CONCLUSIONS: Although additional well-designed longitudinal clinical studies are needed, the results of this systematic review suggest that some systemic diseases may be correlated with endodontic outcomes.
Authors: Stella M F Lima; Mirna S Freire; Ana Paula C Cantuária; Danilo C M Martins; Ingrid A Amorim; Elaine M G L Dantas; Jade O Farias; Márcio B Castro; Jackson S Silva; Fernando A Barriviera; Maurício Barriviera; Jeeser A Almeida; Isadora A Uehara; Marcelo J B Silva; Ana Paula L Oliveira; Osmar N Silva; Robert E W Hancock; Octávio L Franco; Taia M B Rezende Journal: Clin Oral Investig Date: 2020-11-16 Impact factor: 3.573
Authors: Michael Solomonov; Hyeon-Cheol Kim; Avi Hadad; Dan Henry Levy; Joe Ben Itzhak; Oleg Levinson; Hadas Azizi Journal: Restor Dent Endod Date: 2020-03-04