A Lefebvre1, X Bertrand2, C Quantin3, P Vanhems4, J-C Lucet5, G Nuemi6, K Astruc7, P Chavanet8, L S Aho-Glélé7. 1. Service d'épidémiologie et hygiène hospitalières, CHU Dijon, France; Laboratoire Microbiologie Environnementale et Risques Sanitaires, Dijon, France. Electronic address: alefebvre@chu-reims.fr. 2. Université Paris Diderot, Paris, France; Service d'hygiène, CHU Besançon, France. 3. Biostatistics and Bioinformatics (DIM), University Hospital, Bourgogne Franche-Comté University, Dijon, France; INSERM, CIC 1432, Dijon University Hospital, Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Dijon, France; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Paris, France. 4. Service d'Hygiène Hospitalière, Epidémiologie et Prévention, groupe hospitalier Edouard Herriot, Lyon, France. 5. Equipe d'épidémiologie et santé publique, Université Claude Bernard, Lyon, France; UHLIN, groupe hospitalier Bichat - Claude Bernard, HUPNVS, AP-HP, Paris, France. 6. Biostatistics and Bioinformatics (DIM), University Hospital, Bourgogne Franche-Comté University, Dijon, France; INSERM, CIC 1432, Dijon University Hospital, Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Dijon, France. 7. Service d'épidémiologie et hygiène hospitalières, CHU Dijon, France. 8. Laboratoire Chrono-environnement, UMR CNRS 6249, Université de Franche-Comté, Besançon, France; Département de maladies infectieuses, CHU Dijon, France.
Abstract
OBJECTIVE: To study the association between the results of water samples and Pseudomonas aeruginosa healthcare-associated cases in a French university hospital. METHODS: Generalized Estimating Equations were used on complete case and imputed datasets. The spatial unit was the building and the time unit was the quarter. RESULTS: For the period 2004-2013, 2932 water samples were studied; 17% were positive for P. aeruginosa. A higher incidence of P. aeruginosa cases was associated with a higher proportion of positive water samples (P=0.056 in complete case analysis and P=0.031 with the imputed dataset). The association was no longer observed when haematology and intensive care units were excluded, but was significant in analyses of data concerning intensive care units alone (P<0.001). CONCLUSION: This study suggests that water outlet contamination in hospitals can lead to an increase in healthcare-associated P. aeruginosa cases in wards dealing with susceptible patients, but does not play a significant role in other wards.
OBJECTIVE: To study the association between the results of water samples and Pseudomonas aeruginosa healthcare-associated cases in a French university hospital. METHODS: Generalized Estimating Equations were used on complete case and imputed datasets. The spatial unit was the building and the time unit was the quarter. RESULTS: For the period 2004-2013, 2932 water samples were studied; 17% were positive for P. aeruginosa. A higher incidence of P. aeruginosa cases was associated with a higher proportion of positive water samples (P=0.056 in complete case analysis and P=0.031 with the imputed dataset). The association was no longer observed when haematology and intensive care units were excluded, but was significant in analyses of data concerning intensive care units alone (P<0.001). CONCLUSION: This study suggests that water outlet contamination in hospitals can lead to an increase in healthcare-associated P. aeruginosa cases in wards dealing with susceptible patients, but does not play a significant role in other wards.
Authors: Victoria Rutherford; Kelly Yom; Egon A Ozer; Olivia Pura; Ami Hughes; Katherine R Murphy; Laura Cudzilo; David Mitchell; Alan R Hauser Journal: Environ Microbiol Rep Date: 2018-08 Impact factor: 3.541