Sarah M Böker1, Yvonne Y Bender2, Lisa C Adams3, Eva M Fallenberg4, Moritz Wagner5, Bernd Hamm6, Marcus R Makowski7. 1. Department of Radiology, Charité, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: Sarah-maria.boeker@charite.de. 2. Department of Radiology, Charité, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: Yi-na.bender@charite.de. 3. Department of Radiology, Charité, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: Lisa.adams@charite.de. 4. Department of Radiology, Charité, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: Eva.fallenberg@charite.de. 5. Department of Radiology, Charité, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: Moritz.wagner@charite.de. 6. Department of Radiology, Charité, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: Bernd.hamm@charite.de. 7. Department of Radiology, Charité, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: Marcus.makowski@charite.de.
Abstract
PURPOSE: To evaluate the diagnostic performance of susceptibility-weighted magnetic resonance imaging (SWMR) for the differentiation of sclerotic and non-sclerotic Modic changes (MC) of the spine compared to computed tomography (CT) and radiographs. MATERIALS AND METHODS: The Institutional Ethics-Review-Board approved this prospective study in advance. Written consent was obtained from all subjects. SWMR and standard T1/T2 MR of the cervical (n=21) and/or lumbar spine (n=34) were performed in 54 patients. 21 patients served as control. 18 patients were evaluated with CT; in all other patients radiographs were available. 67 Modic changes were identified on T1/T2 MR. On SWMR changes were classified as sclerotic and non-sclerotic based on signal intensity measurements. The sensitivity and specificity of SWMR and T1/T2 MR for differentiating between sclerotic and non-sclerotic Modic changes were determined with CT and radiographs as reference standard. RESULTS: On SWMR, signal measurements between sclerotic and non-sclerotic Modic changes differed significantly (p<0.01). On T1- and T2-weighted MR no significant difference (p>0.05) was measured. On SWMR, a reliable differentiation between sclerotic and non-sclerotic Modic changes could be achieved, with a sensitivity of 100% and specificity of 95%. In contrast, the combination of T1-/T2-weighted MR yielded a significantly lower sensitivity to detect sclerosis (20%). CONCLUSION: SWMR allows a reliable detection of sclerosis in Modic changes with a higher accuracy compared to standard spine MR sequences, using radiographs and CT as reference standard.
PURPOSE: To evaluate the diagnostic performance of susceptibility-weighted magnetic resonance imaging (SWMR) for the differentiation of sclerotic and non-sclerotic Modic changes (MC) of the spine compared to computed tomography (CT) and radiographs. MATERIALS AND METHODS: The Institutional Ethics-Review-Board approved this prospective study in advance. Written consent was obtained from all subjects. SWMR and standard T1/T2 MR of the cervical (n=21) and/or lumbar spine (n=34) were performed in 54 patients. 21 patients served as control. 18 patients were evaluated with CT; in all other patients radiographs were available. 67 Modic changes were identified on T1/T2 MR. On SWMR changes were classified as sclerotic and non-sclerotic based on signal intensity measurements. The sensitivity and specificity of SWMR and T1/T2 MR for differentiating between sclerotic and non-sclerotic Modic changes were determined with CT and radiographs as reference standard. RESULTS: On SWMR, signal measurements between sclerotic and non-sclerotic Modic changes differed significantly (p<0.01). On T1- and T2-weighted MR no significant difference (p>0.05) was measured. On SWMR, a reliable differentiation between sclerotic and non-sclerotic Modic changes could be achieved, with a sensitivity of 100% and specificity of 95%. In contrast, the combination of T1-/T2-weighted MR yielded a significantly lower sensitivity to detect sclerosis (20%). CONCLUSION: SWMR allows a reliable detection of sclerosis in Modic changes with a higher accuracy compared to standard spine MR sequences, using radiographs and CT as reference standard.
Authors: Sarah M Böker; Lisa C Adams; Ute Lina Fahlenkamp; Gerd Diederichs; Bernd Hamm; Marcus R Makowski Journal: Sci Rep Date: 2020-12-01 Impact factor: 4.379