Laura González-Saiz1, Carmen Fiuza-Luces2, Fabian Sanchis-Gomar3, Alejandro Santos-Lozano4, Carlos A Quezada-Loaiza5, Angela Flox-Camacho5, Diego Munguía-Izquierdo6, Ignacio Ara7, Alfredo Santalla8, María Morán2, Paz Sanz-Ayan9, Pilar Escribano-Subías5, Alejandro Lucia10. 1. Research Institute Hospital 12 de Octubre ('i+12'), Madrid, Spain. 2. Research Institute Hospital 12 de Octubre ('i+12'), Madrid, Spain; Spanish Network for Biomedical Research in Rare Diseases (CIBERER), U723, Spain. 3. Department of Physiology, Faculty of Medicine, University of Valencia and Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain; Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, USA. Electronic address: fabian.sanchis@uv.es. 4. Research Institute Hospital 12 de Octubre ('i+12'), Madrid, Spain; Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, USA; GIDFYS, European University Miguel de Cervantes, Valladolid, Spain. 5. Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, Madrid, Spain. 6. Department of Sports and Computer Science, Section of Physical Education and Sports, Universidad Pablo de Olavide, Seville, Spain. 7. GENUD Toledo Research Group, Universidad de Castilla-La Mancha, Toledo, Spain. 8. Research Institute Hospital 12 de Octubre ('i+12'), Madrid, Spain; Department of Sports and Computer Science, Section of Physical Education and Sports, Universidad Pablo de Olavide, Seville, Spain. 9. Pulmonary Hypertension Unit, Department of Rehabilitation, Hospital Universitario 12 de Octubre, Madrid, Spain. 10. Research Institute Hospital 12 de Octubre ('i+12'), Madrid, Spain; European University, Madrid, Spain.
Abstract
BACKGROUND:Pulmonary arterial hypertension is often associated with skeletal-muscle weakness. The purpose of this randomized controlled trial was to determine the effects of an 8-week intervention combining muscle resistance, aerobic and inspiratory pressure-load exercises on upper/lower-body muscle power and other functional variables in patients with this disease. METHODS: Participants were allocated to a control (standard care) or intervention (exercise) group (n=20 each, 45±12 and 46±11years, 60% women and 10% patients with chronic thromboembolic pulmonary hypertension per group). The intervention included five, three and six supervised (inhospital) sessions/week of aerobic, resistance and inspiratory muscle training, respectively. The primary endpoint was peak muscle power during bench/leg press; secondary outcomes included N-terminal pro-brain natriuretic peptide levels, 6-min walking distance, five-repetition sit-to-stand test, maximal inspiratory pressure, cardiopulmonary exercise testing variables (e.g., peak oxygen uptake), health-related quality of life, physical activity levels, and safety. RESULTS: Adherence to training sessions averaged 94±0.5% (aerobic), 98±0.3% (resistance) and 91±1% (inspiratory training). Analysis of variance showed a significant interaction (group×time) effect for leg/bench press (P<0.001/P=0.002), with both tests showing an improvement in the exercise group (P<0.001) but not in controls (P>0.1). We found a significant interaction effect (P<0.001) for five-repetition sit-to-stand test, maximal inspiratory pressure and peak oxygen uptake (P<0.001), indicating a training-induced improvement. No major adverse event was noted due to exercise. CONCLUSIONS: An 8-week exercise intervention including aerobic, resistance and specific inspiratory muscle training is safe for patients with pulmonary arterial hypertension and yields significant improvements in muscle power and other functional variables.
RCT Entities:
BACKGROUND:Pulmonary arterial hypertension is often associated with skeletal-muscle weakness. The purpose of this randomized controlled trial was to determine the effects of an 8-week intervention combining muscle resistance, aerobic and inspiratory pressure-load exercises on upper/lower-body muscle power and other functional variables in patients with this disease. METHODS:Participants were allocated to a control (standard care) or intervention (exercise) group (n=20 each, 45±12 and 46±11years, 60% women and 10% patients with chronic thromboembolic pulmonary hypertension per group). The intervention included five, three and six supervised (inhospital) sessions/week of aerobic, resistance and inspiratory muscle training, respectively. The primary endpoint was peak muscle power during bench/leg press; secondary outcomes included N-terminal pro-brain natriuretic peptide levels, 6-min walking distance, five-repetition sit-to-stand test, maximal inspiratory pressure, cardiopulmonary exercise testing variables (e.g., peak oxygen uptake), health-related quality of life, physical activity levels, and safety. RESULTS: Adherence to training sessions averaged 94±0.5% (aerobic), 98±0.3% (resistance) and 91±1% (inspiratory training). Analysis of variance showed a significant interaction (group×time) effect for leg/bench press (P<0.001/P=0.002), with both tests showing an improvement in the exercise group (P<0.001) but not in controls (P>0.1). We found a significant interaction effect (P<0.001) for five-repetition sit-to-stand test, maximal inspiratory pressure and peak oxygen uptake (P<0.001), indicating a training-induced improvement. No major adverse event was noted due to exercise. CONCLUSIONS: An 8-week exercise intervention including aerobic, resistance and specific inspiratory muscle training is safe for patients with pulmonary arterial hypertension and yields significant improvements in muscle power and other functional variables.
Authors: Karen S W Chia; Christine T Shiner; Karen Brown; Cameron J Holloway; Camila Moreyra; Nicole Bart; Peter K K Wong; Steven G Faux; Eugene Kotlyar Journal: Pulm Circ Date: 2022-05-11 Impact factor: 2.886
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Authors: Anna R Hemnes; Luke G Silverman-Lloyd; Shi Huang; Grant MacKinnon; Jeffrey Annis; Carolyn S Whitmore; Ravinder Mallugari; Rashundra N Oggs; Rezzan Hekmat; Rongzi Shan; Pauline P Huynh; Chang Yu; Seth S Martin; Michael J Blaha; Evan L Brittain Journal: Chest Date: 2021-04-17 Impact factor: 10.262
Authors: Alejandro Santos-Lozano; Paz Sanz-Ayan; Laura González-Saiz; Carlos A Quezada-Loaiza; Carmen Fiuza-Luces; Angela Flox-Camacho; Diego Munguía-Izquierdo; Alfredo Santalla; María Morán; Pilar Escribano-Subías; Alejandro Lucia Journal: Data Brief Date: 2017-03-18
Authors: Diego Fernández-Lázaro; David Gallego-Gallego; Luis A Corchete; Darío Fernández Zoppino; Jerónimo J González-Bernal; Blanca García Gómez; Juan Mielgo-Ayuso Journal: Int J Environ Res Public Health Date: 2021-06-22 Impact factor: 3.390