António Robalo Nunes1,2,3, Cândida Fonseca1,4,5, Filipa Marques1,4,5, Aurora Belo1, Dialina Brilhante1,6, José Cortez1,5,6. 1. Anemia Working Group - Portugal, Lisbon, Portugal. 2. Geriatric University Unit, Lisbon University Medical School, Lisbon, Portugal. 3. Northern Lisbon Hospital Center, Lisbon, Portugal. 4. West Lisbon Hospital Center, Lisbon, Portugal. 5. NOVA Medical School, Nova University of Lisbon, Lisbon, Portugal. 6. Francisco Gentil Portuguese Institute of Oncology, Lisbon Center, Lisbon, Portugal.
Abstract
AIM: The present study aimed to characterize the prevalence of anemia and iron deficiency in older Portuguese adults, and to compare it with the prevalence in younger individuals. METHODS: A population-based, cross-sectional study (EMPIRE study) enrolling a representative sample of 6267 adults aged <65 years and 1617 adults aged ≥65 years was carried out. Hemoglobin, ferritin, creatinine and C-reactive protein levels were measured by Point-of-Care tests. RESULTS: Anemia was more prevalent (P < 0.001) in participants aged ≥80 years (31.4%) compared with participants aged <65 years (19.6%) and 65-79 years (17.3%). At a 30-ng/mL ferritin cut-off, iron deficiency was more prevalent in participants aged ≥80 years (42.8%) compared with participants aged <65 years (31.5%) and 65-79 years (30.2%). Alternative ferritin cut-offs showed overall similar patterns. Anemia and iron deficiency were significantly more prevalent in older individuals who self-reported heart failure, coronary heart disease and gastritis. Anemia was more prevalent in participants aged <65 years in the north of Portugal and participants aged ≥65 years in central Portugal, following the prevalence of iron deficiency in the regions. In all regions, anemia was more prevalent in participants aged ≥80 years (reaching 39.0% in Lisbon and Tagus Valley, and 51.0% in the south). CONCLUSIONS: Anemia and iron deficiency are highly prevalent in older Portuguese adults, particularly among those aged ≥80 years. Better diagnosis, prevention and treatment strategies should be implemented taking into account the outstanding role of iron deficiency in older Portuguese adults, the differences between regions and the intrinsic characteristics of this population. Geriatr Gerontol Int 2017; 17: 1814-1822.
AIM: The present study aimed to characterize the prevalence of anemia and iron deficiency in older Portuguese adults, and to compare it with the prevalence in younger individuals. METHODS: A population-based, cross-sectional study (EMPIRE study) enrolling a representative sample of 6267 adults aged <65 years and 1617 adults aged ≥65 years was carried out. Hemoglobin, ferritin, creatinine and C-reactive protein levels were measured by Point-of-Care tests. RESULTS:Anemia was more prevalent (P < 0.001) in participants aged ≥80 years (31.4%) compared with participants aged <65 years (19.6%) and 65-79 years (17.3%). At a 30-ng/mL ferritin cut-off, iron deficiency was more prevalent in participants aged ≥80 years (42.8%) compared with participants aged <65 years (31.5%) and 65-79 years (30.2%). Alternative ferritin cut-offs showed overall similar patterns. Anemia and iron deficiency were significantly more prevalent in older individuals who self-reported heart failure, coronary heart disease and gastritis. Anemia was more prevalent in participants aged <65 years in the north of Portugal and participants aged ≥65 years in central Portugal, following the prevalence of iron deficiency in the regions. In all regions, anemia was more prevalent in participants aged ≥80 years (reaching 39.0% in Lisbon and Tagus Valley, and 51.0% in the south). CONCLUSIONS:Anemia and iron deficiency are highly prevalent in older Portuguese adults, particularly among those aged ≥80 years. Better diagnosis, prevention and treatment strategies should be implemented taking into account the outstanding role of iron deficiency in older Portuguese adults, the differences between regions and the intrinsic characteristics of this population. Geriatr Gerontol Int 2017; 17: 1814-1822.
Authors: Maud Wieczorek; Franziska Schwarz; Angélique Sadlon; Lauren A Abderhalden; Caroline de Godoi Rezende Costa Molino; Donat R Spahn; Dominik J Schaer; E John Orav; Andreas Egli; Heike A Bischoff-Ferrari Journal: Aging Clin Exp Res Date: 2021-09-17 Impact factor: 3.636
Authors: Alenka Stahl-Gugger; Caroline de Godoi Rezende Costa Molino; Maud Wieczorek; Patricia O Chocano-Bedoya; Lauren A Abderhalden; Dominik J Schaer; Donat R Spahn; E John Orav; Bruno Vellas; José A P da Silva; Reto W Kressig; Andreas Egli; Heike A Bischoff-Ferrari Journal: Aging Clin Exp Res Date: 2022-03-18 Impact factor: 4.481