Ryota Sakurai1,2,3,4, Kenji Ishii5, Masashi Yasunaga1, Rumi Takeuchi1, Yoh Murayama1, Naoko Sakuma6, Muneyuki Sakata5, Keiichi Oda5,7, Kenji Ishibashi5, Kiichi Ishiwata5, Yoshinori Fujiwara1, Manuel Montero-Odasso2. 1. Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. 2. Gait and Brain Lab, Parkwood Institute, University of Western Ontario and Lawson Health Research Institute, London, Ontario, Canada. 3. Faculty of Sport Sciences, Waseda University, Saitama, Japan. 4. Research Fellow of the Japan Society for the Promotion of Science, Japan Society for the Promotion of Science, Tokyo, Japan. 5. Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. 6. Research Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. 7. Department of Radiological Technology, Faculty of Health Sciences, Hokkaido University of Science, Hokkaido, Japan.
Abstract
AIM: Understanding the relationship between age-related gait impairment, such as slow gait, and executive functioning in seniors may help identify individuals at higher risk of mobility decline, falls, and progression to dementia at earlier stages. We aim to identify brain regions concomitantly associated with poor gait and executive functioning in a cohort of well-functioning elderly women. METHODS: In total, 149 well-functioning women aged 70.1 ± 6.2 years underwent FDG-PET to evaluate regional cerebral metabolic rates of glucose normalized in reference to cerebellar glucose metabolic value (normalized-rCMRglc) in 16 brain areas. We assessed gait speed, step length and cadence under usual and fast conditions. Executive function was assessed using Trail-Making-Tests (TMT) A and B. RESULTS: Adjusted multiple regression analyses for potential covariates showed that TMT-B and ΔTMT (TMT B-A) were associated with gait speed and cadence at fast condition. Lower normalized-rCMRglc in the posterior cingulate and primary sensorimotor cortices were associated with longer TMT-B and ΔTMT times (i.e., lower executive function) as well as with slower gait speed and lower cadence at fast condition. Slower gait speed and lower cadence at fast condition were also associated with lower normalized-rCMRglc in the occipital and parietal cortices. There were no other significant associations. CONCLUSIONS: In healthy elderly women without impending disability or cognitive impairment, reduced glucose metabolism in the posterior cingulate and primary sensorimotor cortices were associated with both lower gait performance and executive functioning. Our results suggest that gait control and executive functions might share the same neural substrate. Geriatr Gerontol Int 2017; 17: 1873-1880.
AIM: Understanding the relationship between age-related gait impairment, such as slow gait, and executive functioning in seniors may help identify individuals at higher risk of mobility decline, falls, and progression to dementia at earlier stages. We aim to identify brain regions concomitantly associated with poor gait and executive functioning in a cohort of well-functioning elderly women. METHODS: In total, 149 well-functioning women aged 70.1 ± 6.2 years underwent FDG-PET to evaluate regional cerebral metabolic rates of glucose normalized in reference to cerebellar glucose metabolic value (normalized-rCMRglc) in 16 brain areas. We assessed gait speed, step length and cadence under usual and fast conditions. Executive function was assessed using Trail-Making-Tests (TMT) A and B. RESULTS: Adjusted multiple regression analyses for potential covariates showed that TMT-B and ΔTMT (TMT B-A) were associated with gait speed and cadence at fast condition. Lower normalized-rCMRglc in the posterior cingulate and primary sensorimotor cortices were associated with longer TMT-B and ΔTMT times (i.e., lower executive function) as well as with slower gait speed and lower cadence at fast condition. Slower gait speed and lower cadence at fast condition were also associated with lower normalized-rCMRglc in the occipital and parietal cortices. There were no other significant associations. CONCLUSIONS: In healthy elderly women without impending disability or cognitive impairment, reduced glucose metabolism in the posterior cingulate and primary sensorimotor cortices were associated with both lower gait performance and executive functioning. Our results suggest that gait control and executive functions might share the same neural substrate. Geriatr Gerontol Int 2017; 17: 1873-1880.
Authors: Andrea L Rosso; Andrea L Metti; Kimberly Faulkner; Mark Redfern; Kristine Yaffe; Lenore Launer; C Elizabeth Shaaban; Neelesh K Nadkarni; Caterina Rosano Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Elkin Garcia-Cifuentes; Felipe Botero-Rodríguez; Felipe Ramirez Velandia; Angela Iragorri; Isabel Marquez; Geronimo Gelvis-Ortiz; María-Fernanda Acosta; Alberto Jaramillo-Jimenez; Francisco Lopera; Carlos Alberto Cano-Gutiérrez Journal: Front Neurol Date: 2022-02-18 Impact factor: 4.003