Literature DB >> 28188792

Recruitment of PP1 to the centrosomal scaffold protein CEP192.

Isha Nasa1, Laura Trinkle-Mulcahy2, P Douglas3, Sibapriya Chaudhuri1, S P Lees-Miller3, Kyung S Lee4, Greg B Moorhead5.   

Abstract

Centrosomal protein of 192 kDa (CEP192) is a scaffolding protein that recruits the mitotic protein kinases Aurora A and PLK1 to the centrosome. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif. The threonine of the KHVTF motif is phosphorylated during mitosis and protein kinase inhibition studies suggest this to be a PLK1-dependent process.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  CEP192; Centrosome; Mitosis; Polo-like kinase one; Protein phosphatase one

Mesh：

Substances：

Year:  2017        PMID： 28188792      PMCID： PMC7888556          DOI： 10.1016/j.bbrc.2017.02.004

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  32 in total

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Journal:  Methods Mol Biol       Date:  2007

3.  Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation.

Authors:  Vladimir Joukov; Arcangela De Nicolo; Alison Rodriguez; Johannes C Walter; David M Livingston
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-19       Impact factor: 11.205

4.  Sequence logos: a new way to display consensus sequences.

Authors:  T D Schneider; R M Stephens
Journal:  Nucleic Acids Res       Date:  1990-10-25       Impact factor: 16.971

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Authors:  P Dent; D G Campbell; F B Caudwell; P Cohen
Journal:  FEBS Lett       Date:  1990-01-01       Impact factor: 4.124

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Authors:  Hue T Tran; Annegret Ulke; Nick Morrice; Christine J Johannes; Greg B G Moorhead
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Authors:  G Moorhead; R W MacKintosh; N Morrice; T Gallagher; C MacKintosh
Journal:  FEBS Lett       Date:  1994-12-12       Impact factor: 4.124
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Journal:  Sci Rep       Date:  2019-05-17       Impact factor: 4.379

4.  A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome.

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  5 in total

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