Mohammad Alizadeh1, Hamed Khodaei2, Mehran Mesgari Abbasi3, Sevda Saleh-Ghadimi4. 1. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2. Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. 3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 4. Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract
BACKGROUND: 5-Hydroxymethylfurfural (5-HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti-allergic effect of 5-HMF by investigating some selected components of the immune response in BALB/c mice immunised with ovalbumin (OVA). RESULTS: Immunised animals had an increased level of serum total and OVA-specific antibodies when compared to the control (P < 0.01).We found that the OVA-induced increase in serum IgE and OVA-specific IgE were significantly suppressed in the groups treated with 5-HMF (P < 0.05). Moreover, interleukin-4 (IL-4) and interferon gamma (IFN-γ) were significantly reduced in a dose-independent manner when compared to the sensitised group (P < 0.05). CONCLUSION: 5-HMF inhibited the up-regulation of total and OVA-specific IgE through the suppression of the Th2-type immune response in immunised BALB/c mice. 5-HMF could therefore be a novel therapeutic approach for the prevention of IgE-mediated allergic diseases.
BACKGROUND:5-Hydroxymethylfurfural (5-HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti-allergic effect of 5-HMF by investigating some selected components of the immune response in BALB/c mice immunised with ovalbumin (OVA). RESULTS: Immunised animals had an increased level of serum total and OVA-specific antibodies when compared to the control (P < 0.01).We found that the OVA-induced increase in serum IgE and OVA-specific IgE were significantly suppressed in the groups treated with 5-HMF (P < 0.05). Moreover, interleukin-4 (IL-4) and interferon gamma (IFN-γ) were significantly reduced in a dose-independent manner when compared to the sensitised group (P < 0.05). CONCLUSION:5-HMF inhibited the up-regulation of total and OVA-specific IgE through the suppression of the Th2-type immune response in immunised BALB/c mice. 5-HMF could therefore be a novel therapeutic approach for the prevention of IgE-mediated allergic diseases.
Authors: Wed Mohammed Ali Alaerjani; Sraa Abu-Melha; Rahaf Mohammed Hussein Alshareef; Badriah Saad Al-Farhan; Hamed A Ghramh; Badria Mohammed Abdallah Al-Shehri; Majed A Bajaber; Khalid Ali Khan; Munira M Alrooqi; Gad Allah Modawe; Mohammed Elimam Ahamed Mohammed Journal: Molecules Date: 2022-07-23 Impact factor: 4.927