| Literature DB >> 28188441 |
Andresa Borges Soares1, Elizabeth Ferreira Martinez2, Patricia Fernandes Avila Ribeiro2, Icleia Siqueira Barreto2, Maria Cássia Aguiar3, Cristiane Furuse4, Marcelo Sperandio2, Victor Angelo Montalli2, Ney Soares de Araújo2, Vera Cavalcanti de Araújo2.
Abstract
There is mounting evidence on the importance of some biological processes in tumor growth, such as vascular supply, apoptosis, autophagy, and senescence. We have investigated these processes in polymorphous low-grade adenocarcinoma (PLGA), in an attempt to identify those that are relevant for this particular lesion. We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. Our results showed that PLGA growth does not depend on newly formed vessels but only on preexisting vasculature. Furthermore, PLGA is promoted by autophagy, sustained by both anti-apoptotic and anti-senescence signals, and stimulated by Bcl-2 and survivin.Entities:
Keywords: Angiogenesis; Apoptosis; Autophagy; Bcl2; LC3B; Polymorphous low-grade adenocarcinoma; Senescence; Survivin
Mesh：
Substances：
Year: 2017 PMID： 28188441 DOI： 10.1007/s00428-017-2085-3
Source DB: PubMed Journal: Virchows Arch ISSN： 0945-6317 Impact factor: 4.064