Khin P Kilgore1, Michael S Lee2, Jacqueline A Leavitt3, Bahram Mokri4, David O Hodge5, Ryan D Frank5, John J Chen6. 1. College of Medicine, Mayo Clinic, Jacksonville, Florida; Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida. 2. Department of Neuro-Ophthalmology, University of Minnesota, Minneapolis, Minnesota. 3. Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida. 4. Department of Neurology, Mayo Clinic, Jacksonville, Florida. 5. Department of Health Sciences Research/Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida. 6. Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida. Electronic address: chen.john@mayo.edu.
Abstract
PURPOSE: To re-evaluate the population-based incidence of idiopathic intracranial hypertension (IIH) and to determine if it mirrors the rise in obesity. DESIGN: Retrospective, population-based cohort. PARTICIPANTS: All residents of Olmsted County, Minnesota, diagnosed with IIH between January 1, 1990, and December 31, 2014. METHODS: All cases of IIH were identified using the Rochester Epidemiology Project, which is a record-linkage system of medical records for all patient-physician encounters among Olmsted County, Minnesota, residents. All medical records were reviewed to confirm a diagnosis of IIH. The incidence rates of IIH were compared against the incidence of obesity in Minnesota over the same period. MAIN OUTCOME MEASURES: Incidence of IIH, lumbar puncture opening pressures, and body mass index. RESULTS: There were 63 new cases of IIH, yielding an overall age- and gender-adjusted annual incidence of 1.8 per 100 000 (95% confidence interval, 1.3-2.2) between 1990 and 2014. It increased from 1.0 per 100 000 (1990-2001) to 2.4 per 100 000 (2002-2014; P = 0.007). The incidence of IIH was 3.3 per 100 000 in women and 0.3 per 100 000 in men (P ≤ 0.001). In obese women 15 to 44 years of age, the incidence was 22.0 per 100 000 compared with 6.8 per 100 000 among all women in the same age group. A strong correlation was observed between IIH incidence rates and obesity rates in Minnesota (R2 = 0.70, P = 0.008). CONCLUSIONS: The incidence of IIH has increased since 1990, which is highly correlated with the rise in obesity during the same period.
PURPOSE: To re-evaluate the population-based incidence of idiopathic intracranial hypertension (IIH) and to determine if it mirrors the rise in obesity. DESIGN: Retrospective, population-based cohort. PARTICIPANTS: All residents of Olmsted County, Minnesota, diagnosed with IIH between January 1, 1990, and December 31, 2014. METHODS: All cases of IIH were identified using the Rochester Epidemiology Project, which is a record-linkage system of medical records for all patient-physician encounters among Olmsted County, Minnesota, residents. All medical records were reviewed to confirm a diagnosis of IIH. The incidence rates of IIH were compared against the incidence of obesity in Minnesota over the same period. MAIN OUTCOME MEASURES: Incidence of IIH, lumbar puncture opening pressures, and body mass index. RESULTS: There were 63 new cases of IIH, yielding an overall age- and gender-adjusted annual incidence of 1.8 per 100 000 (95% confidence interval, 1.3-2.2) between 1990 and 2014. It increased from 1.0 per 100 000 (1990-2001) to 2.4 per 100 000 (2002-2014; P = 0.007). The incidence of IIH was 3.3 per 100 000 in women and 0.3 per 100 000 in men (P ≤ 0.001). In obesewomen 15 to 44 years of age, the incidence was 22.0 per 100 000 compared with 6.8 per 100 000 among all women in the same age group. A strong correlation was observed between IIH incidence rates and obesity rates in Minnesota (R2 = 0.70, P = 0.008). CONCLUSIONS: The incidence of IIH has increased since 1990, which is highly correlated with the rise in obesity during the same period.
Authors: R J Blanch; C Vasseneix; A Liczkowski; A Yiangou; A Aojula; J A Micieli; S P Mollan; N J Newman; V Biousse; B B Bruce; A Sinclair Journal: Eye (Lond) Date: 2019-02-19 Impact factor: 3.775
Authors: Rita Laiginhas; Marta Guimarães; Pedro Cardoso; Hugo Santos-Sousa; John Preto; Mário Nora; João Chibante; Fernando Falcão-Reis; Manuel Falcão Journal: Obes Surg Date: 2019-07 Impact factor: 4.129
Authors: Khin P Kilgore; Michael S Lee; Jacqueline A Leavitt; Ryan D Frank; Collin M McClelland; John J Chen Journal: Am J Ophthalmol Date: 2018-09-21 Impact factor: 5.258