Vincent C Woo1. 1. Section of Endocrinology and Metabolism, Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: vincent.woo@umanitoba.ca.
Abstract
PURPOSE: The treatment of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) using insulin is not ideal at this time. Despite advances made with basal insulin analogues, many individuals achieve less than optimal glycemic control or are at risk for hypoglycemia. Currently available basal insulin analogues do not deliver steady, peakless, continuous insulin for >24 hours and are associated with adverse events, including hypoglycemia. The objective of this paper was to review the clinical efficacy and safety of upcoming long-acting insulin analogues such as insulin degludec and insulin glargine 300 U/mL (Gla-300). METHODS: A comprehensive literature search of PubMed and Google Scholar was conducted from 1966 to 2015. The search included randomized controlled trials that specifically assessed the efficacy and safety of insulin degludec and Gla-300 in patients with T1DM and T2DM. FINDINGS: The efficacy of insulin degludec and Gla-300 in achieving glycemic control has been reported in clinical trials in adults with T1DM and T2DM. Not only did a large number of patients succeed in meeting glycosylated hemoglobin targets, but they also experienced reductions in hypoglycemic events. These 2 therapies are associated with a reduced risk of nocturnal hypoglycemia and are generally well tolerated. IMPLICATIONS: The long-acting insulin analogues insulin degludec and Gla-300 are promising therapies in the treatment of T1DM and T2DM. Their improved insulin delivery for >24 hours offers glycemic control with a good safety profile.
PURPOSE: The treatment of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) using insulin is not ideal at this time. Despite advances made with basal insulin analogues, many individuals achieve less than optimal glycemic control or are at risk for hypoglycemia. Currently available basal insulin analogues do not deliver steady, peakless, continuous insulin for >24 hours and are associated with adverse events, including hypoglycemia. The objective of this paper was to review the clinical efficacy and safety of upcoming long-acting insulin analogues such as insulin degludec and insulin glargine 300 U/mL (Gla-300). METHODS: A comprehensive literature search of PubMed and Google Scholar was conducted from 1966 to 2015. The search included randomized controlled trials that specifically assessed the efficacy and safety of insulin degludec and Gla-300 in patients with T1DM and T2DM. FINDINGS: The efficacy of insulin degludec and Gla-300 in achieving glycemic control has been reported in clinical trials in adults with T1DM and T2DM. Not only did a large number of patients succeed in meeting glycosylated hemoglobin targets, but they also experienced reductions in hypoglycemic events. These 2 therapies are associated with a reduced risk of nocturnal hypoglycemia and are generally well tolerated. IMPLICATIONS: The long-acting insulin analogues insulin degludec and Gla-300 are promising therapies in the treatment of T1DM and T2DM. Their improved insulin delivery for >24 hours offers glycemic control with a good safety profile.
Authors: Monika Lechleitner; Martin Clodi; Heidemarie Abrahamian; Helmut Brath; Johanna Brix; Heinz Drexel; Peter Fasching; Bernhard Föger; Claudia Francesconi; Elke Fröhlich-Reiterer; Jürgen Harreiter; Sabine E Hofer; Friedrich Hoppichler; Joakim Huber; Susanne Kaser; Alexandra Kautzky-Willer; Bernhard Ludvik; Anton Luger; Julia K Mader; Bernhard Paulweber; Thomas Pieber; Rudolf Prager; Birgit Rami-Merhar; Michael Resl; Michaela Riedl; Michael Roden; Christoph H Saely; Christian Schelkshorn; Guntram Schernthaner; Harald Sourij; Lars Stechemesser; Harald Stingl; Hermann Toplak; Thomas C Wascher; Raimund Weitgasser; Yvonne Winhofer-Stöckl; Sandra Zlamal-Fortunat Journal: Wien Klin Wochenschr Date: 2019-05 Impact factor: 1.704
Authors: Wafa A Alsofiani; Bandar H Alessa; Fahad Alsabaan; Abdullah U Althemery; Aliah M Ghith; Abdullah A Alfaifi Journal: Diabetes Metab Syndr Obes Date: 2022-03-05 Impact factor: 3.168