Literature DB >> 28186082

Both sides of the same coin: Rac1 splicing regulating by EGF signaling.

Xiang-Dong Fu1.   

Abstract

EGF, a well-studied mitogen for cancer cells, is revealed to induce an E3 ubiquitin ligase adaptor SPSB1, which recruits the Elongin B/C-Collin complex to trigger ubiquitylation of the negative splicing regulator hnRNP A1. This event is synergized with EGF-activated SR proteins to alter alternative splicing of a key small GTPase Rac1 to enhance cell migration, highlighting converging EGF signals on both negative and positive splicing regulators to jointly promote a key cancer pathway.

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Year:  2017        PMID： 28186082      PMCID： PMC5385611          DOI： 10.1038/cr.2017.19

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  15 in total

1.  Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase.

Authors:  Dennis Fiegen; Lars-Christian Haeusler; Lars Blumenstein; Ulrike Herbrand; Radovan Dvorsky; Ingrid R Vetter; Mohammad R Ahmadian
Journal:  J Biol Chem       Date:  2003-11-18       Impact factor: 5.157

2.  The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.

Authors:  Zhihong Zhou; Jinsong Qiu; Wen Liu; Yu Zhou; Ryan M Plocinik; Hairi Li; Qidong Hu; Gourisanker Ghosh; Joseph A Adams; Michael G Rosenfeld; Xiang-Dong Fu
Journal:  Mol Cell       Date:  2012-06-21       Impact factor: 17.970

3.  SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling.

Authors:  Feng Wang; Xing Fu; Peng Chen; Ping Wu; Xiaojuan Fan; Na Li; Hong Zhu; Ting-Ting Jia; Hongbin Ji; Zefeng Wang; Catherine C L Wong; Ronggui Hu; Jingyi Hui
Journal:  Cell Res       Date:  2017-01-13       Impact factor: 25.617

Review 4.  Context-dependent control of alternative splicing by RNA-binding proteins.

Authors:  Xiang-Dong Fu; Manuel Ares
Journal:  Nat Rev Genet       Date:  2014-08-12       Impact factor: 53.242

5.  Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing.

Authors:  Federico Pelisch; Davitte Khauv; Guillermo Risso; Melody Stallings-Mann; Matías Blaustein; Leandro Quadrana; Derek C Radisky; Anabella Srebrow
Journal:  J Cell Biochem       Date:  2012-07       Impact factor: 4.429

6.  An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.

Authors:  G Zhu; Z Fan; M Ding; H Zhang; L Mu; Y Ding; Y Zhang; B Jia; L Chen; Z Chang; W Wu
Journal:  Oncogene       Date:  2015-03-09       Impact factor: 9.867

Review 7.  Feedback regulation of EGFR signalling: decision making by early and delayed loops.

Authors:  Roi Avraham; Yosef Yarden
Journal:  Nat Rev Mol Cell Biol       Date:  2011-02       Impact factor: 94.444

8.  Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways.

Authors:  Vânia Gonçalves; Paulo Matos; Peter Jordan
Journal:  Hum Mol Genet       Date:  2009-07-13       Impact factor: 6.150

9.  p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.

Authors:  Andrei V Bakin; Cammie Rinehart; Anne K Tomlinson; Carlos L Arteaga
Journal:  J Cell Sci       Date:  2002-08-01       Impact factor: 5.285

10.  The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation.

Authors:  W van der Houven van Oordt; M T Diaz-Meco; J Lozano; A R Krainer; J Moscat; J F Cáceres
Journal:  J Cell Biol       Date:  2000-04-17       Impact factor: 10.539
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  6 in total

1.  β-Arrestin2 Is Critically Involved in the Differential Regulation of Phosphosignaling Pathways by Thyrotropin-Releasing Hormone and Taltirelin.

Authors:  Zdenka Drastichova; Radka Trubacova; Jiri Novotny
Journal:  Cells       Date:  2022-04-27       Impact factor: 7.666

2.  TSVdb: a web-tool for TCGA splicing variants analysis.

Authors:  Wenjie Sun; Ting Duan; Panmeng Ye; Kelie Chen; Guanling Zhang; Maode Lai; Honghe Zhang
Journal:  BMC Genomics       Date:  2018-05-29       Impact factor: 3.969

Review 3.  Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase.

Authors:  Laurie G Hudson; Jennifer M Gillette; Huining Kang; Melanie R Rivera; Angela Wandinger-Ness
Journal:  Cancers (Basel)       Date:  2018-09-27       Impact factor: 6.639

4.  Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition.

Authors:  Longzheng Xia; Jingguan Lin; Jian Su; Linda Oyang; Heran Wang; Shiming Tan; Yanyan Tang; Xiaoyan Chen; Wenbin Liu; Xia Luo; Yutong Tian; Jiaxin Liang; Qi Su; Qianjin Liao; Yujuan Zhou
Journal:  Onco Targets Ther       Date:  2019-07-16       Impact factor: 4.147

5.  Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment.

Authors:  Xuan Liu; Xue-Qing Zhou; Xu-Wei Shang; Li Wang; Yi Li; Hong Yuan; Fu-Qiang Hu
Journal:  J Zhejiang Univ Sci B       Date:  2020-03       Impact factor: 3.066

6.  Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy.

Authors:  Milad Ashrafizadeh; Ali Zarrabi; Kiavash Hushmandi; Farid Hashemi; Ebrahim Rahmani Moghadam; Mehdi Raei; Mahshad Kalantari; Shima Tavakol; Reza Mohammadinejad; Masoud Najafi; Franklin R Tay; Pooyan Makvandi
Journal:  ACS Comb Sci       Date:  2020-10-23       Impact factor: 3.784
  6 in total

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