Literature DB >> 2818581

Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction.

I Semsei1, G Rao, A Richardson.   

Abstract

The activities of superoxide dismutase (Cu/Zn) and catalase were observed to decrease significantly between 6 and 29 months of age in rat liver. The decrease in superoxide dismutase and catalase activity was paralleled by a decrease in the levels of the mRNA species coding for these enzymes and the nuclear transcription of the superoxide dismutase and catalase genes. Life-long dietary restriction was shown to increase the expression (i.e. activities, mRNA levels, and nuclear transcription) of superoxide dismutase and catalase in liver tissue from 18-month-old rats.

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Year:  1989        PMID： 2818581     DOI： 10.1016/0006-291x(89)91505-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  23 in total

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