C Kuhli-Hattenbach1, P Hellstern2, W Miesbach3, T Kohnen4, L-O Hattenbach5. 1. Klinik für Augenheilkunde, Klinikum der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Deutschland. hattenbach@med.uni-frankfurt.de. 2. Klinik für Hämostaseologie und Transfusionsmedizin, Klinikum Ludwigshafen, Ludwigshafen am Rhein, Deutschland. 3. Medizinische Klinik II, Institut für Transfusionsmedizin und Immunhämatologie, Klinikum der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Deutschland. 4. Klinik für Augenheilkunde, Klinikum der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Deutschland. 5. Augenklinik des Klinikums Ludwigshafen, Ludwigshafen am Rhein, Deutschland.
Abstract
BACKGROUND: The potential impact of multiple thrombophilic defects on retinal venous occlusive (RVO) diseases with regard to age and various risk factors has not been studied extensively. MATERIALS AND METHODS: In a retrospective, multicenter study, thrombophilia data of 128 patients <65 years of age with RVO and 110 healthy subjects were evaluated. The main measure outcome was the prevalence of multiple thrombophilic disorders. RESULTS: Multiple thrombophilic defects were significantly more prevalent among RVO patients (18.0%) than among controls (1.8%; P < 0.0001). We identified factor VIII elevation, elevated lipoprotein(a) plasma levels and resistance to activated protein C as the most prevalent combined disorders. Factor XII deficiency and prothrombin mutation G20210A were found to be isolated thrombophilic risk factors. Multiple thrombophilic defects were significantly associated with RVO recurrence (P = 0.008). CONCLUSION: Multiple thrombophilic disorders are associated with the development of RVO among patients younger than 65 years of age. Moreover, our results suggest that patients with RVO associated with underlying combined thrombophilic defects are at increased risk for RVO recurrence. Further studies are required to analyze whether the diagnosis of combined thrombophilic defects among RVO patients could be a predictor for RVO recurrence.
BACKGROUND: The potential impact of multiple thrombophilic defects on retinal venous occlusive (RVO) diseases with regard to age and various risk factors has not been studied extensively. MATERIALS AND METHODS: In a retrospective, multicenter study, thrombophilia data of 128 patients <65 years of age with RVO and 110 healthy subjects were evaluated. The main measure outcome was the prevalence of multiple thrombophilic disorders. RESULTS:Multiple thrombophilic defects were significantly more prevalent among RVO patients (18.0%) than among controls (1.8%; P < 0.0001). We identified factor VIII elevation, elevated lipoprotein(a) plasma levels and resistance to activated protein C as the most prevalent combined disorders. Factor XII deficiency and prothrombin mutation G20210A were found to be isolated thrombophilic risk factors. Multiple thrombophilic defects were significantly associated with RVO recurrence (P = 0.008). CONCLUSION:Multiple thrombophilic disorders are associated with the development of RVO among patients younger than 65 years of age. Moreover, our results suggest that patients with RVO associated with underlying combined thrombophilic defects are at increased risk for RVO recurrence. Further studies are required to analyze whether the diagnosis of combined thrombophilic defects among RVO patients could be a predictor for RVO recurrence.
Authors: J W McLean; J E Tomlinson; W J Kuang; D L Eaton; E Y Chen; G M Fless; A M Scanu; R M Lawn Journal: Nature Date: 1987 Nov 12-18 Impact factor: 49.962
Authors: Astrid van Hylckama Vlieg; Linda E Flinterman; Lance A Bare; Suzanne C Cannegieter; Pieter H Reitsma; Andre R Arellano; Carmen H Tong; James J Devlin; Frits R Rosendaal Journal: Circ Cardiovasc Genet Date: 2014-09-10
Authors: A Sodi; B Giambene; R Marcucci; F Sofi; P Bolli; R Abbate; D Prisco; U Menchini Journal: Eur J Ophthalmol Date: 2008 Mar-Apr Impact factor: 2.597