Tomoko Takano1, Hitoshi Tajiri2, Satoyo Hosono3, Ayano Inui4, Jun Murakami5, Kosuke Ushijima6, Yoko Miyoshi7, Yuri Etani8, Daiki Abukawa9, Mitsuyoshi Suzuki10, Stephen Brooks11. 1. Department of Pediatrics, Osaka General Medical Center, 3-1-56 Bandaihigashi, Sumiyoshi-ku, Osaka, 558-8558, Japan. takano@gh.opho.jp. 2. Department of Pediatrics, Osaka General Medical Center, 3-1-56 Bandaihigashi, Sumiyoshi-ku, Osaka, 558-8558, Japan. 3. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan. 4. Department of Pediatric Hepatology and Gastroenterology, Saiseikai Yokohama City Tobu Hospital, Yokohama, Japan. 5. Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University, Tottori, Japan. 6. Department of Pediatrics, Kurume University Medical Center, Kurume, Japan. 7. Department of Pediatrics, Osaka University Hospital, Suita, Japan. 8. Department of Pediatric Gastroenterology, Nutrition and Endocrinology, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan. 9. Department of General Pediatrics, Miyagi Children's Hospital, Sendai, Japan. 10. Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan. 11. Department of Microbiology/Immunology, State University of New York at Buffalo, Buffalo, USA.
Abstract
BACKGROUND: It is necessary to evaluate the natural history of children with hepatitis B virus (HBV) infection in each country to consider their long-term management. METHODS: A multi-center observational study of children with chronic HBV infection who were diagnosed at age ≤15 years was carried out in 18 hospitals in Japan. RESULTS: We reviewed children with HBV infection including 381 with mother-to-child transmission (MTCT) and 154 with horizontal transmission, genotype C being the most prevalent virus genotype (83%). Children with horizontal transmission were more frequently infected with HBV genotype A or B and more likely to receive interferon therapy than those infected by MTCT. The HBeAg seroconversion rate at 15 years of age was 42% in the MTCT group and 38% in the horizontal group. It was lower in children with genotype C infection than in those infected with other genotypes (33 versus 45%). Hepatitis developed at any age but before 4 years of age the incidence was high in the horizontal group. At 3 years after the onset of the hepatitis, 26% of children with MTCT and 30% of those with horizontal transmission became inactive carriers. The incidences of hepatocellular carcinoma (HCC) at 30 years of age were 6% in the MTCT group and 11% in the horizontal group. CONCLUSIONS: Patients with childhood-onset HBV infection with MTCT and horizontal transmission developed hepatitis and seroconverted to anti-HBe at any age and had a lifetime risk of developing HCC.
BACKGROUND: It is necessary to evaluate the natural history of children with hepatitis B virus (HBV) infection in each country to consider their long-term management. METHODS: A multi-center observational study of children with chronic HBV infection who were diagnosed at age ≤15 years was carried out in 18 hospitals in Japan. RESULTS: We reviewed children with HBV infection including 381 with mother-to-child transmission (MTCT) and 154 with horizontal transmission, genotype C being the most prevalent virus genotype (83%). Children with horizontal transmission were more frequently infected with HBV genotype A or B and more likely to receive interferon therapy than those infected by MTCT. The HBeAg seroconversion rate at 15 years of age was 42% in the MTCT group and 38% in the horizontal group. It was lower in children with genotype C infection than in those infected with other genotypes (33 versus 45%). Hepatitis developed at any age but before 4 years of age the incidence was high in the horizontal group. At 3 years after the onset of the hepatitis, 26% of children with MTCT and 30% of those with horizontal transmission became inactive carriers. The incidences of hepatocellular carcinoma (HCC) at 30 years of age were 6% in the MTCT group and 11% in the horizontal group. CONCLUSIONS:Patients with childhood-onset HBV infection with MTCT and horizontal transmission developed hepatitis and seroconverted to anti-HBe at any age and had a lifetime risk of developing HCC.
Authors: Maureen M Jonas; Joan M Block; Barbara A Haber; Saul J Karpen; W Thomas London; Karen F Murray; Michael R Narkewicz; Philip Rosenthal; Kathleen B Schwarz; Brian J McMahon Journal: Hepatology Date: 2010-10-01 Impact factor: 17.425
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Authors: M J Tong; C Q Pan; S-H B Han; D S-K Lu; S Raman; K-Q Hu; J K Lim; H W Hann; A D Min Journal: Aliment Pharmacol Ther Date: 2018-02-26 Impact factor: 8.171