| Literature DB >> 28183997 |
S Noushin Emami1,2, Bo G Lindberg1, Susanna Hua1, Sharon R Hill2, Raimondas Mozuraitis3,4, Philipp Lehmann5, Göran Birgersson2, Anna-Karin Borg-Karlson3, Rickard Ignell2, Ingrid Faye6.
Abstract
Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s.l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a P. falciparum-infected blood meal, sporogony is increased.Entities:
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Year: 2017 PMID： 28183997 DOI： 10.1126/science.aah4563
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728