Literature DB >> 28182231

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia.

Mirko Baruscotti1, Annalisa Bucchi1, Raffaella Milanesi1, Manuel Paina1, Andrea Barbuti1, Tomaso Gnecchi-Ruscone2, Elisabetta Bianco3, Laura Vitali-Serdoz4, Riccardo Cappato, Dario DiFrancesco1.   

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Year:  2017        PMID： 28182231     DOI： 10.1093/eurheartj/ehv582

Source DB:  PubMed          Journal:  Eur Heart J        ISSN： 0195-668X            Impact factor:   29.983


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  27 in total

Review 1.  Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If "funny" current.

Authors:  Mirko Baruscotti; Elisabetta Bianco; Annalisa Bucchi; Dario DiFrancesco
Journal:  J Interv Card Electrophysiol       Date:  2016-01-18       Impact factor: 1.900

2.  Computational analysis of the human sinus node action potential: model development and effects of mutations.

Authors:  Alan Fabbri; Matteo Fantini; Ronald Wilders; Stefano Severi
Journal:  J Physiol       Date:  2017-04-01       Impact factor: 5.182

3.  Unmissable Papers, 2017.

Authors: 
Journal:  Arrhythm Electrophysiol Rev       Date:  2018-03

4.  Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function.

Authors:  Stephanie Biel; Marco Aquila; Brigitte Hertel; Anne Berthold; Thomas Neumann; Dario DiFrancesco; Anna Moroni; Gerhard Thiel; Silke Kauferstein
Journal:  Pflugers Arch       Date:  2016-08-23       Impact factor: 3.657

5.  Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia.

Authors:  Stephen Boulton; Madoka Akimoto; Sam Akbarizadeh; Giuseppe Melacini
Journal:  J Biol Chem       Date:  2017-02-07       Impact factor: 5.157

6.  Altered cyclic nucleotide binding and pore opening in a diseased human HCN4 channel.

Authors:  Leo C T Ng; Yue Xian Li; Filip Van Petegem; Eric A Accili
Journal:  Biophys J       Date:  2022-02-24       Impact factor: 3.699

Review 7.  Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond.

Authors:  Pietro Mesirca; Isabelle Bidaud; Matteo E Mangoni
Journal:  J Physiol       Date:  2016-08-02       Impact factor: 5.182

8.  Familial inappropriate sinus tachycardia: a new chapter in the story of HCN4 channelopathies.

Authors:  Vasanth Vedantham; Melvin M Scheinman
Journal:  Eur Heart J       Date:  2017-01-21       Impact factor: 35.855

9.  Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes.

Authors:  Colin H Peters; Pin W Liu; Stefano Morotti; Stephanie C Gantz; Eleonora Grandi; Bruce P Bean; Catherine Proenza
Journal:  Proc Natl Acad Sci U S A       Date:  2021-07-13       Impact factor: 11.205

Review 10.  Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery.

Authors:  Paola Imbrici; Antonella Liantonio; Giulia M Camerino; Michela De Bellis; Claudia Camerino; Antonietta Mele; Arcangela Giustino; Sabata Pierno; Annamaria De Luca; Domenico Tricarico; Jean-Francois Desaphy; Diana Conte
Journal:  Front Pharmacol       Date:  2016-05-10       Impact factor: 5.810
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