Literature DB >> 2818204

Pharmacokinetics of pralidoxime chloride. A comparative study in healthy volunteers and in organophosphorus poisoning.

D Jovanović1.   

Abstract

The pharmacokinetics of a cholinesterase reactivating oxime, 2-PAM, was comparatively studied in healthy volunteers and in persons suffering from poisoning by organophosphorus insecticides. The elevation of plasma concentrations of the oxime and prolongation of its "effective half-life" were noticed in poisoned individuals. These changes were attributed to the disturbed general hemodynamics and reduced renal blood flow in organophosphorus intoxication rather than to the direct renal toxicity of anticholinesterases.

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Year:  1989        PMID： 2818204     DOI： 10.1007/BF00303133

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  14 in total

1.  Minimum concentrations of N-methylpyridinium-2-aldoxime methane sulphonate (P2S) which reverse neuromuscular block.

Authors:  A SUNDWALL
Journal:  Biochem Pharmacol       Date:  1961-12       Impact factor: 5.858

2.  The dependence of the blood level of the oxime HS-6 on the severity of organophosphate poisoning.

Authors:  O L Wolthuis; H J Clason-Van Der Wiel; R Visser
Journal:  Eur J Pharmacol       Date:  1976-10       Impact factor: 4.432

3.  Pharmacokinetics and efficacies of obidoxime and atropine in paraoxon poisoning.

Authors:  K Schoene; A König; H Oldiges; M Krügel
Journal:  Arch Toxicol       Date:  1988-04       Impact factor: 5.153

4.  Pharmacokinetics of pralidoxime chloride and its correlation to therapeutic efficacy against diisopropyl fluorophosphate intoxication in rats.

Authors:  K Jeevarathinam; A K Ghosh; A Srinivasan; S Das Gupta
Journal:  Pharmazie       Date:  1988-02       Impact factor: 1.267

5.  Renal tubular secretion of pralidoxime in man.

Authors:  R D Swartz; F R Sidell
Journal:  Proc Soc Exp Biol Med       Date:  1974-06

6.  [Selection of the method for the determination of oxime content in biological material].

Authors:  M Maksimović; V Vojvodić
Journal:  Arh Hig Rada Toksikol       Date:  1969       Impact factor: 1.948

7.  [Change in overall hemodynamics and renal blood flow in acute organophosphorus compound poisoning].

Authors:  I G Chursin; I P Shevtsov; V M Rybalko; M K Samulevich
Journal:  Voen Med Zh       Date:  1980-02

8.  Intramuscular and intravenous administration of small doses of 2-pyridinium aldoxime methochloride to man.

Authors:  F R Sidell; W A Groff
Journal:  J Pharm Sci       Date:  1971-08       Impact factor: 3.534

9.  Effect of poisoning by soman (pinacolyl methylphosphonofluoridate) on the serum half-life of the cholinesterase reactivator HI-6 in mice.

Authors:  J G Clement; K J Simons; C J Briggs
Journal:  Biopharm Drug Dispos       Date:  1988 Mar-Apr       Impact factor: 1.627

10.  [Changes in the ultrastruct of the rat kidney after intoxication with organophosphates (author's transl)].

Authors:  H Hettwer
Journal:  Acta Histochem       Date:  1975       Impact factor: 2.479
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  6 in total

Review 1.  Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures.

Authors:  Charles M Thompson; John M Gerdes; Henry F VanBrocklin
Journal:  Neurobiol Dis       Date:  2019-04-22       Impact factor: 5.996

2.  Dual acting oximes designed for therapeutic decontamination of reactive organophosphates via catalytic inactivation and acetylcholinesterase reactivation.

Authors:  Jayme Cannon; Shengzhuang Tang; Kelly Yang; Racquel Harrison; Seok Ki Choi
Journal:  RSC Med Chem       Date:  2021-08-04

Review 3.  Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.

Authors:  Biljana Antonijevic; Milos P Stojiljkovic
Journal:  Clin Med Res       Date:  2007-03

4.  Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients.

Authors:  J L Willems; J P Langenberg; A G Verstraete; M De Loose; B Vanhaesebroeck; G Goethals; F M Belpaire; W A Buylaert; D Vogelaers; F Colardyn
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

5.  In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs).

Authors:  Erin Gallagher; Il Minn; Janice E Chambers; Peter C Searson
Journal:  Fluids Barriers CNS       Date:  2016-07-11

Review 6.  Nanomaterial-Enabled Sensors and Therapeutic Platforms for Reactive Organophosphates.

Authors:  Seok Ki Choi
Journal:  Nanomaterials (Basel)       Date:  2021-01-16       Impact factor: 5.076
  6 in total

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