| Literature DB >> 28181550 |
Ben Ma, Tian Liao, Duo Wen, Chuanpeng Dong, Li Zhou, Shuwen Yang, Yu Wang, Qinghai Ji.
Abstract
Entities:
Year: 2017 PMID: 28181550 PMCID: PMC5299956 DOI: 10.1038/srep42321
Source DB: PubMed Journal: Sci Rep ISSN: 2045-2322 Impact factor: 4.379
Clinicopathological characteristics of PTC patients in the FUSCC and TCGA cohorts.
| Variables | TCGA ( | FUSCC ( | |||
|---|---|---|---|---|---|
| % | % | ||||
| Age (years) | 0.099 | ||||
| <45 | 217 | 46.1 | 99 | 53.5 | |
| ≥45 | 254 | 53.9 | 86 | 46.5 | |
| Gender | 0.374 | ||||
| Male | 126 | 26.8 | 43 | 23.2 | |
| Female | 345 | 73.2 | 142 | 76.8 | |
| Multifocality | |||||
| Unifocal | 250 | 54.2 | 135 | 73.0 | |
| Multifocal | 211 | 45.8 | 50 | 27.0 | |
| Histological type | |||||
| Classical PTC | 329 | 70.9 | 183 | 98.9 | |
| Follicular PTC | 99 | 21.3 | 2 | 1.1 | |
| Tall-cell PTC | 36 | 7.8 | 0 | 0 | |
| Coexistent HT | |||||
| Yes | 66 | 14.0 | 44 | 23.8 | |
| No | 405 | 86.0 | 141 | 76.2 | |
| ETE | |||||
| No | 313 | 66.5 | 168 | 90.8 | |
| Yes | 144 | 30.6 | 17 | 9.2 | |
| NA | 14 | 3.0 | 0 | 0 | |
| T Stage | |||||
| T1-T2 | 282 | 59.9 | 166 | 89.7 | |
| T3-T4 | 188 | 39.9 | 19 | 10.3 | |
| NA | 1 | 0.2 | 0 | 0 | |
| LNM | |||||
| N0 | 215 | 45.6 | 85 | 45.9 | |
| N1 | 210 | 44.6 | 100 | 54.1 | |
| NA | 46 | 9.8 | 0 | 0 | |
| M | |||||
| M0 | 263 | 55.8 | 185 | 100 | |
| M1 | 8 | 1.7 | 0 | 0 | |
| NA | 200 | 42.5 | 0 | 0 | |
| TNM Stage | |||||
| I-II | 312 | 66.2 | 152 | 82.1 | |
| III-IV | 157 | 33.3 | 33 | 17.9 | |
| NA | 2 | 0.4 | 0 | 0 | |
| Mutation | 222 | 47.1 | 103 | 55.7 | |
| Wild-type | 177 | 37.6 | 79 | 42.7 | |
| NA | 72 | 15.3 | 3 | 1.6 | |
Notes: Italic and bold type indicates statistical significance. Abbreviations: PTC, papillary thyroid cancer; FUSCC, Fudan University Shanghai Cancer Center; TCGA, The Cancer Genomics Atlas; HT, Hashimoto’s thyroiditis; ETE, extrathyroidal extension; LNM, lymph node metastasis; M, metastasis; TNM, tumor-node-metastasis.
Cox proportional hazards analysis of factors associated with RFS for PTC patients in TCGA cohort.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95.0% CI for HR | HR | 95.0% CI for HR | |||
| Ageb | 1.016 | 0.992–1.040 | 0.977 | 1.000 | 0.968–1.034 | |
| Genderb | ||||||
| Male | 1 | 1 | ||||
| Female | 0.350 | 0.159–0.769 | 0.386 | 0.172–0.868 | ||
| Multifocality | ||||||
| Unifocal | 1 | |||||
| Multifocal | 0.106 | 1.933 | 0.868–4.300 | |||
| Histological subtypesb | ||||||
| Classical PTC | 1 | 1 | ||||
| Follicular PTC | 0.913 | 0.941 | 0.318–2.786 | 0.871 | 1.095 | 0.367–3.269 |
| Tall-cell PTC | 0.202 | 2.229 | 0.650–7.641 | 0.886 | 1.098 | 0.306–3.949 |
| Coexistent HT | ||||||
| No | 1 | |||||
| Yes | 0.740 | 1.729 | 0.648–4.616 | |||
| ETE | ||||||
| No | 1 | |||||
| Yes | 0.182 | 1.712 | 0.777–3.773 | |||
| T stageb | ||||||
| T1-T2 | 1 | 1 | ||||
| T3-T4 | 2.294 | 1.010–5.211 | 0.508 | 1.401 | 0.516–3.806 | |
| LNM | ||||||
| No | 1 | |||||
| Yes | 0.111 | 2.077 | 0.846–5.100 | |||
| TNM stageb | ||||||
| Stage I-II | 1 | 1 | ||||
| Stage III-IV | 0.052 | 2.176 | 0.992–4.773 | 0.664 | 1.326 | 0.371–4.738 |
| Wild-type | 1 | |||||
| Mutation | 0.365 | 1.557 | 0.597–4.057 | |||
| LINC00271b | ||||||
| ≥cutoff | 1 | 1 | ||||
| <cutoffc | 3.688 | 1.384–9.829 | 3.182 | 1.160–8.726 | ||
Notes: aItalic and bold type indicates statistical significance; badjusted by age, gender, histological subtypes, T stage, TNM stage and LINC00271 in multivariate analysis; c, LINC00271 expression level less than the best cutoff value for prediction of recurrence; Abbreviations: PTC, papillary thyroid cancer; TCGA, The Cancer Genomics Atlas; OR, odds ratio; CI, confidence interval; HT, Hashimoto’s thyroiditis; ETE, extrathyroidal extension; LNM, lymph node metastasis; TNM, tumor-node-metastasis.